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This medication comes with important safety warnings that you should be aware of before use. These warnings highlight potential risks and necessary precautions. Please consider these carefully and consult your healthcare provider if you have any questions or concerns.

• High Blood Pressure with Pheochromocytoma: Avoid using glucagon (Glucagen) if you have a pheochromocytoma, a rare tumor located near the adrenal glands. Glucagon can cause a dangerous rise in blood pressure due to hormone release. If you have this condition, discuss alternative treatments for low blood sugar with your healthcare provider.

• Low Blood Sugar with Insulinoma: Glucagon (Glucagen) should not be used if you have an insulinoma, a pancreatic tumor that can lead to excessive insulin release, risking severe low blood sugar. Consult your healthcare provider for other ways to manage low blood sugar if you have this tumor.

• Severe Allergic Reactions: Be aware that glucagon (Glucagen) can cause severe allergic reactions, including facial swelling, shock, or anaphylaxis. Seek immediate medical help if you experience symptoms such as hives, rash, swelling of the lips or tongue, or difficulty breathing after administration.

• Effectiveness Concerns: Glucagon (Glucagen) requires adequate liver sugar reserves to be effective. It may not work well if you have a history of poor diet, prolonged low blood sugar, or adrenal gland issues. Discuss alternative treatments for low blood sugar with your healthcare provider if these conditions apply to you.

• Imaging Procedure Risks: When used for imaging procedures, glucagon (Glucagen) can cause high blood sugar in individuals with diabetes and may lead to high blood pressure or rapid heart rate in those with heart conditions. Your healthcare provider will monitor these changes and provide necessary treatments during the procedure.

Contraindications:
This medication should not be used under the following conditions due to potential health risks. Consult your healthcare provider if you have any of these:

• Presence of pheochromocytoma.
• Having an insulinoma (tumor that causes excess insulin production).
• Use as a diagnostic tool in the presence of a glucagonoma (tumor that causes excess glucagon production).

Always consult with your healthcare provider to ensure this medication is safe for your specific health conditions.

When using GlucaGen as a diagnostic aid, it's important to be aware of potential interactions with other medications:

• Beta-Blockers: These medications, often prescribed for heart conditions, may cause a temporary increase in pulse and blood pressure when combined with GlucaGen. Patients with coronary artery disease should be monitored, as this effect might require treatment.

• Indomethacin: A nonsteroidal anti-inflammatory drug (NSAID), indomethacin can reduce GlucaGen's ability to raise blood sugar levels, potentially leading to hypoglycemia. Blood glucose levels should be closely monitored in patients taking indomethacin.

• Anticholinergic Drugs: When used together with GlucaGen, these medications can increase the risk of gastrointestinal side effects due to their combined effect on slowing down gut movement. It's generally advised to avoid using anticholinergic drugs alongside GlucaGen during diagnostic procedures.

• Warfarin: GlucaGen may enhance the blood-thinning effects of warfarin, increasing the risk of bleeding. Patients on warfarin should be monitored for unusual bruising or bleeding, and adjustments to the warfarin dosage may be necessary.

• Insulin: Since insulin works opposite to glucagon, using GlucaGen as a diagnostic aid in patients receiving insulin requires careful monitoring of blood sugar levels to prevent unexpected changes.

Always inform your healthcare provider about all medications you're taking before undergoing diagnostic procedures involving GlucaGen to ensure safe and effective use.