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This document provides essential safety and warning information regarding the use of glucagon (Glucagen). It is important to understand the potential risks and conditions under which this medication should be used with caution. Please consult your healthcare provider if you have any questions or concerns.

• High Blood Pressure in Pheochromocytoma Patients: Glucagon (Glucagen) is not recommended for individuals with a rare adrenal gland tumor known as pheochromocytoma. The medication can induce hormone release, leading to dangerously elevated blood pressure. Consult your healthcare provider for alternative treatments for low blood sugar if you have this condition.

• Low Blood Sugar in Insulinoma Patients: Avoid using glucagon (Glucagen) if you have insulinoma, a pancreatic tumor. The drug may cause an increase in insulin secretion, resulting in severe hypoglycemia. Your healthcare provider can suggest other management strategies for low blood sugar if you have this tumor.

• Severe Allergic Reactions: There is a risk of serious allergic reactions, including facial swelling, shock, and anaphylaxis, when using glucagon (Glucagen). Seek immediate medical attention if you experience symptoms such as hives, skin rash, swelling of the lips or tongue, or difficulty breathing.

• Effectiveness Issues: Glucagon (Glucagen) may be less effective if you have a poor diet or issues with your adrenal glands, as it requires proper liver sugar storage. Discuss other options with your healthcare provider if you suffer from prolonged low blood sugar due to these conditions.

• Complications in Imaging Procedures: Using glucagon (Glucagen) during imaging procedures may cause high blood sugar in diabetics and high blood pressure or increased heart rate in those with heart conditions. Your provider will monitor your condition and provide necessary treatment during the procedure.

Contraindications: Glucagon (Glucagen) should not be used in the following situations due to potential serious health risks:

• Patients with pheochromocytoma.
• Patients with insulinoma.
• As a diagnostic tool in individuals with glucagonoma, a tumor producing excessive glucagon.

Consult your healthcare provider if any of these conditions apply to you before using glucagon (Glucagen).

When using this medication, you might experience some mild side effects such as nausea, vomiting, headache, dizziness, or reactions at the injection site like irritation, redness, or swelling. These effects are usually not serious, but if they persist or worsen, it is advisable to consult your healthcare provider for guidance.

In some cases, individuals may encounter other side effects like low blood pressure, weakness, sleepiness, or diarrhea. While these are not as common, it is important to discuss them with your healthcare provider if they occur, particularly if they are bothersome or severe.

Rarely, this medication can cause serious side effects that require immediate medical attention. These include a fast or pounding heartbeat and severe allergic reactions characterized by hives, itching, swelling of the face, tongue, or throat, and difficulty breathing. Should you experience any of these symptoms, it is crucial to seek urgent medical care.

Remember that this overview is not exhaustive, and if you notice any other unexpected effects, it's important to inform your healthcare provider. The benefits of the medication are generally considered to outweigh the risks of side effects for most people using it.