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The following information outlines important safety considerations and potential risks associated with the use of diazoxide (Proglycem). Please read these points carefully and consult your healthcare provider if you have any questions or concerns:

• Fluid Retention: This medication can lead to fluid retention, which may exacerbate conditions such as heart failure. Diuretics may be prescribed to help manage this side effect by promoting increased urination. Discuss any worries or the possibility of this side effect with your healthcare provider.

• Ketoacidosis Risk: Diazoxide (Proglycem) has the potential to cause ketoacidosis, a serious condition characterized by an excess buildup of acid in the body. This risk is heightened in individuals with pre-existing illnesses. If you experience symptoms like nausea, vomiting, stomach pain, fatigue, or difficulty breathing, discontinue use immediately and seek medical advice.

• Pulmonary Hypertension in Infants: There is a risk of developing a severe lung condition known as pulmonary hypertension, particularly in infants and newborns receiving high doses of diazoxide (Proglycem). This condition has shown improvement or resolution upon stopping the medication. It is crucial to discuss any concerns with your healthcare provider.

There are currently no known contraindications for diazoxide (Proglycem).

While using this medication, some individuals may experience mild side effects such as nausea, a loss of appetite, stomach upset, headaches, dizziness, and changes in taste. Additionally, there might be an unusual growth of body hair, particularly on the forehead, back, arms, and legs, although this is typically temporary and resolves after stopping the medication. These effects are generally not serious but should be monitored. If any persist or worsen, consider consulting a healthcare provider.

This medication can also cause sodium and fluid retention, which might lead to more serious conditions like heart problems. Be vigilant for signs such as swelling in the arms, legs, hands, or feet, unexplained weight gain, shortness of breath, and unusual tiredness. These symptoms warrant immediate medical attention due to their potential severity. Additionally, the drug may elevate blood sugar levels, potentially resulting in symptoms like frequent urination, excessive thirst, persistent nausea or vomiting, abdominal pain, fruity-smelling breath, rapid breathing, and unexpected weight loss. It's crucial to monitor blood sugar levels regularly and report any significant changes to a healthcare provider.

There are also less common but severe side effects that demand urgent care, such as easy bruising or bleeding, fainting, a rapid or pounding heartbeat, and serious allergic reactions. Symptoms of an allergic reaction include rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, and difficulty breathing. Should any of these occur, seek immediate medical assistance. Always remain vigilant and consult healthcare professionals if you notice any other side effects not listed here.

Diazoxide (Proglycem) could affect certain lab tests, like a glucagon test, leading to inaccurate results. It's important to inform lab staff and all your healthcare providers if you're using this medication.

Additionally, Diazoxide may interact with various medications and supplements. Ensure your doctor and pharmacist are aware of all other medications, including prescription, over-the-counter drugs, vitamins, and herbal supplements you are taking. Some interactions may require adjustments to your dosage or usage frequency, especially with medications such as Aceclofenac, Aspirin, Ibuprofen, and many others listed in the source. In some cases, using Diazoxide with specific medications like Aminolevulinic Acid and Trichlormethiazide can increase the risk of side effects, though combined use might be necessary for effective treatment. Your doctor will guide you on any required changes to your medication regimen.