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This information outlines crucial safety details and warnings associated with the use of glipizide. It is essential to review these points carefully and discuss any concerns with your healthcare provider.

• Low Blood Sugar Levels: Glipizide can significantly lower blood sugar levels, especially when combined with other diabetes medications like insulin or if meals are skipped after dosing. Monitoring blood sugar levels is important, particularly when beginning treatment. Be aware of symptoms such as shakiness, anxiety, rapid heartbeat, sweating, confusion, and intense hunger. Increased risk factors include missed meals, alcohol consumption, extended exercise, concurrent use of other blood sugar-lowering drugs, advanced age, and kidney or liver issues.

• Risk of Low Red Blood Cell Count (Hemolytic Anemia): Individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency are at heightened risk for hemolytic anemia when taking medications similar to glipizide. If you experience symptoms like weakness, fatigue, or dizziness, inform your healthcare provider. Alternative medications may be recommended for those with this genetic condition.

• Potential Heart Problems: There is an observed potential risk of serious heart issues, similar to those seen with tolbutamide, another sulfonylurea. If you notice symptoms indicative of a heart attack (chest pain, sweating, nausea, dizziness) or heart failure (breathing difficulties, fatigue, swelling, sudden weight gain), seek immediate medical attention. Your provider may advise hospitalization and discontinuation of glipizide.

• Risk for People with Stomach Issues (Extended-Release Tablets): The non-dissolvable coating of extended-release glipizide could cause issues for those with gastrointestinal problems such as strictures. Patients with these conditions should avoid using the extended-release form.

Contraindications: Glipizide should not be used if you have:

• An allergy to sulfonamide medications
• Type 1 diabetes
• Diabetic ketoacidosis

Please consult your healthcare provider if any of these conditions apply to you before starting glipizide.

When taking this medication, some individuals might experience common side effects, which are generally mild. These include nausea, vomiting, diarrhea, constipation, upset stomach, headache, loss of appetite, gas, weight gain, dizziness, nervousness, tremors, and passing gas. These effects often resolve on their own, but if they persist or worsen, it is advisable to consult a healthcare provider. An empty tablet shell may also appear in your stool, which is harmless.

In some cases, more serious side effects can occur. These include signs of infection like persistent sore throat or fever, unusual tiredness or weakness, unexplained weight gain, mental or mood changes, swollen hands or feet, seizures, and symptoms of liver disease such as abdominal pain, yellowing of the eyes or skin, and dark urine. If you experience any of these, seek medical advice immediately.

This medication can sometimes cause low blood sugar (hypoglycemia), especially if meals are skipped or after intense physical activity. Symptoms include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling in the hands or feet. To address hypoglycemia, carry glucose tablets or eat a quick source of sugar like candy or drink non-diet soda. High blood sugar (hyperglycemia) symptoms include increased thirst and urination; consult your healthcare provider if these occur.

A very serious allergic reaction to this drug is rare but requires urgent medical attention if symptoms such as rash, itching or swelling of the face, tongue, or throat, severe dizziness, or trouble breathing are observed. Always stay vigilant for any other unusual effects and report them to your healthcare provider.

Before starting, stopping, or changing any of your medications, it's important to consult your doctor or pharmacist, especially regarding how it may affect your blood sugar levels. Regularly monitor your blood sugar as advised, and inform your doctor of the results. If you experience symptoms of high or low blood sugar, notify your doctor immediately. Adjustments to your diabetes medication, exercise routine, or diet may be necessary.

Certain medications, including beta-blockers like metoprolol, propranolol, and eye drops such as timolol, can mask the rapid or pounding heartbeat that typically signals low blood sugar (hypoglycemia). However, these medications do not affect other symptoms like dizziness, hunger, or sweating.

Glipizide may interact with a variety of medications and supplements. It is crucial to inform your healthcare provider about all the medications and supplements you are currently taking, both prescribed and over-the-counter, including vitamins and herbal products.

Some medications, such as Acarbose, Aspirin, and various antibiotics and antidiabetics, may require dosage adjustments or special monitoring when used with Glipizide. In some cases, these combinations are necessary, and your doctor will manage how you use them together.

Other medications, including various beta-blockers, antidepressants, and other drugs, may increase the risk of side effects when taken with Glipizide. Nevertheless, these combinations might be the best treatment option for you, and your doctor will adjust your treatment plan accordingly.

Always follow your doctor's guidance on medication usage to ensure safe and effective treatment.