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Grape seed extract is generally considered safe for most individuals when taken in moderate amounts. However, certain groups should exercise caution or avoid its use due to potential risks:

• Individuals with Bleeding Disorders or Scheduled for Surgery: Grape seed extract may act as a blood thinner, increasing the risk of bleeding. Those with bleeding disorders or who are planning to undergo surgery should avoid its use.

• Pregnant or Breastfeeding Women: There is insufficient research on the safety of grape seed extract during pregnancy and breastfeeding. To err on the side of caution, it is recommended that women in these categories avoid its use.

• Individuals with Iron Deficiency: Grape seed extract may reduce the body's ability to absorb iron. Those with iron deficiency should be cautious and consult a healthcare provider before using this supplement.

• People with Grape Allergies: Individuals allergic to grapes may experience allergic reactions to grape seed extract and should avoid its use.

It's essential to consult with a healthcare professional before incorporating grape seed extract into your regimen, especially if you fall into any of these categories.

Common side effects:

• Headache
• Abdominal pain
• Sore throat
• Nausea
• Diarrhea

Serious side effects:

• Serious allergic reaction
• Rash
• Itching or swelling
• Severe dizziness
• Trouble breathing

Grape seed extract, derived from the seeds of grapes, is often used as a dietary supplement due to its antioxidant properties. While it offers potential health benefits, it's important to be aware of how it may interact with certain medications and other supplements.

Blood-Thinning Medications: Grape seed extract may slow blood clotting. When taken alongside anticoagulant or antiplatelet drugs—such as Warfarin, Clopidogrel, or Aspirin—there's an increased risk of bruising and bleeding. Individuals on these medications should consult their healthcare provider before adding grape seed extract to their regimen.

Medications Metabolized by the Liver: The body uses enzymes in the liver, notably those in the cytochrome P450 family, to process various medications. Grape seed extract might influence these enzymes, potentially altering how quickly certain drugs are broken down. This could affect the efficacy and side effects of medications such as Midazolam and phenacetin. It's advisable to discuss with a healthcare professional before combining grape seed extract with medications processed by the liver.

Vitamin C: Combining grape seed extract with vitamin C may lead to an increase in blood pressure in individuals with hypertension. This effect doesn't appear when either supplement is taken alone. Those with high blood pressure should exercise caution and consult a healthcare provider before using these supplements together.

Herbs and Supplements That Slow Blood Clotting: Grape seed extract might slow blood clotting. Taking it with other supplements that have similar effects—such as Garlic, ginger, ginkgo, nattokinase, and Panax ginseng—could increase the risk of bleeding. It's important to be cautious and seek medical advice before combining these supplements.

Given these potential interactions, it's crucial to consult with a healthcare provider before incorporating grape seed extract into your routine, especially if you're taking medications or other supplements. This ensures that you can safely benefit from its properties without adverse effects.