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When taking this medication, you might experience an upset stomach or heartburn. These are common and usually mild, but if they persist or worsen, it’s important to inform your healthcare provider. While serious side effects are uncommon, be vigilant and seek immediate medical attention if you experience severe or persistent nausea or vomiting, easy bruising or bleeding, hearing difficulties, ringing in the ears, changes in urine output, unexplained fatigue, dizziness, dark urine, or yellowing of the eyes or skin.

In rare cases, the drug can cause serious bleeding in the stomach or intestines. Urgent medical care should be sought if you notice severe stomach or abdominal pain, black or tarry stools, vomit resembling coffee grounds, difficulty speaking, unexpected weakness on one side of the body, sudden vision changes, or a sudden severe headache.

Although a serious allergic reaction to this medication is rare, it's critical to get immediate medical help if you experience symptoms such as fever, swollen lymph nodes, rash, severe itching or swelling (particularly of the face, tongue, or throat), intense dizziness, or trouble breathing. Always report any other unexpected effects to your healthcare provider for further advice.

Some medications and products can interact with this drug. These include acetazolamide, blood thinners like warfarin and heparin, corticosteroids such as prednisone, dichlorphenamide, herbal supplements like ginkgo biloba, methotrexate, mifepristone, and valproic acid. Before starting this medication, talk to your doctor if you've recently had any live vaccines, such as the varicella or live flu vaccines.

Read the labels on all your prescription and over-the-counter medicines carefully. Many contain pain relievers or fever reducers, like aspirin and NSAIDs (such as ibuprofen, ketorolac, or naproxen), which are similar to this drug and could increase the likelihood of side effects if combined. Regular use of NSAIDs like ibuprofen may also reduce aspirin's effectiveness in preventing heart attacks or strokes. If you're taking low-dose aspirin for prevention, discuss with your doctor or pharmacist about alternatives for managing pain or fever, like acetaminophen.

This drug can also affect certain laboratory tests, such as specific urine sugar tests, potentially leading to incorrect results. Ensure that all your healthcare providers and lab technicians are aware that you are using this medication.