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The following information outlines critical safety warnings associated with the use of aspirin. It is essential to review these warnings carefully and discuss any concerns with your healthcare provider.

• Stomach Risks: Aspirin may cause stomach irritation, bleeding, or ulcers, particularly if taken with blood thinners or corticosteroids. Individuals over 60, those with a history of stomach issues, or those consuming three or more alcoholic beverages daily are at increased risk. If you experience persistent stomach pain, vomiting blood, or have black stools, seek medical attention immediately.

• Kidney Concerns: High doses of aspirin (325 mg or more) may reduce kidney blood flow, potentially causing damage. This risk is heightened in individuals with existing kidney, liver, or heart conditions, or those taking specific blood pressure medications. Discontinue use and consult your provider if you notice reduced urination, fever, muscle weakness, or a rapid heartbeat.

• Reye's Syndrome in Children: Aspirin is linked to Reye's syndrome, a rare but serious condition, in children recovering from viral infections. Symptoms include vomiting, confusion, and rapid breathing. Immediate medical help is crucial if these symptoms appear. Avoid giving aspirin to children with chickenpox or flu-like symptoms.

• Pregnancy Risks: Pregnant individuals beyond 20 weeks should avoid aspirin doses of 325 mg or higher, as it may harm fetal development, particularly affecting the kidneys and heart. Consult your healthcare provider for safer alternatives for managing pain or fever during pregnancy.

• Allergic Reactions: Though rare, severe allergic reactions to aspirin can occur, presenting as hives, facial swelling, or wheezing. Aspirin may also cause severe skin reactions, such as rashes or blisters. Seek emergency care if these symptoms arise.

• Aspirin Dosage: Always adhere to the prescribed dosage. If advised to take low-dose aspirin (81 mg daily), ensure you do not exceed this amount, as higher doses may not provide the same benefits and could increase side effect risks.

Contraindications:

• Avoid using aspirin if you have an allergy to it or any similar pain or fever relievers. Always consult your healthcare provider if unsure about aspirin use.

Common side effects:

• Upset stomach
• Heartburn

Serious side effects:

• Significant stomach or intestinal bleeding
• Severe abdominal pain
• Black or tarry stools
• Vomit resembling coffee grounds
• Kidney issues
• Changes in urination
• Muscle weakness
• Swelling of the extremities
• Severe allergic reactions
• Fever
• Swollen lymph nodes
• Rash
• Facial swelling
• Difficulty breathing
• Changes in hearing
• Ringing in the ears
• Loss of hearing
• Reye's syndrome
• Confusion
• Rapid breathing
• Seizures
• Liver injury
• Right upper belly pain
• Yellowing of the skin or eyes
• Dark urine

Interactions with high risk of serious adverse effects and should be avoided:

• Warfarin
• heparin
• Ibuprofen

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Acetazolamide
• Prednisone
• dichlorphenamide
• Ginkgo Biloba
• Methotrexate
• Mifepristone
• Valproic Acid
• Ketorolac
• Naproxen