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Please review the following safety information and warnings regarding the use of Humalog (insulin lispro) attentively. Consult with your healthcare provider if you have any questions or concerns.

• Infection Risk from Shared Injection Supplies: Never share Humalog pens, syringes, needles, or cartridges with others. Sharing can significantly increase the risk of transmitting serious infections to yourself and others.

• Hypoglycemia (Low Blood Sugar): Using Humalog alone or with other diabetes medications can cause dangerously low blood sugar levels. This condition can be life-threatening. Always verify the medication labels when using multiple insulin types. Factors increasing this risk include dietary or exercise changes, switching insulins, alcohol consumption, concurrent diabetes medications, and liver or kidney issues.

• Hypokalemia (Low Blood Potassium Levels): Humalog may reduce potassium levels in the blood, posing potential danger. This risk increases if you are on medications that lower potassium, such as diuretics. Regular monitoring of potassium levels by your healthcare provider is essential. Report symptoms like weakness, muscle cramps, nausea, vomiting, or irregular heartbeats promptly.

• Fluid Retention and Heart Failure Risk: Combining Humalog with medications like glitazones (e.g., pioglitazone) can lead to fluid retention, potentially worsening or causing heart failure. Notify your provider of sudden weight gain or heart failure symptoms such as breathlessness, fatigue, or headaches.

• High Blood Sugar and Ketoacidosis with Insulin Pumps: If using an insulin pump for Humalog, ensure it functions correctly. A malfunctioning pump can lead to high blood sugar or diabetic ketoacidosis. Seek immediate assistance if unable to resolve pump issues. Report symptoms such as fatigue, fruity breath, or vomiting to your provider.

Contraindications:

• Do not use Humalog if you are experiencing low blood sugar (hypoglycemia). Always consult your healthcare provider for guidance if this applies to you.

When taking this medication, you may experience some common side effects such as flu-like symptoms, sore throat, runny nose, headache, pain, cough, and infection. These effects are generally mild and should not cause alarm. However, if they persist or worsen, it's advisable to consult your healthcare provider for guidance.

Additionally, some individuals have reported experiencing headache, pain, and infection, albeit less frequently. While these are not typically serious, monitoring their progression is wise and reaching out to a healthcare professional for persistent symptoms is recommended.

There are also more serious side effects to be aware of, though they are uncommon. These include significant weight gain, swelling, and reactions at the injection site like redness, swelling, or itching. If you notice any of these symptoms, it is important to seek medical attention promptly, as they may indicate a more severe reaction.

Furthermore, this medication can affect blood sugar levels. Symptoms of low blood sugar (hypoglycemia) include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling in the hands or feet. Ensuring a regular meal schedule and having quick sources of sugar like glucose tablets or candy on hand can help manage these symptoms. Conversely, symptoms of high blood sugar (hyperglycemia), such as increased thirst and urination, should also be monitored. Speak with your doctor if these occur, as adjustments to your medication, diet, or exercise routine may be necessary.

In rare cases, serious allergic reactions may occur. Watch for signs such as rash, itching, swelling, severe dizziness, or trouble breathing, and seek immediate medical help if these symptoms appear. While this list covers many potential side effects, if you notice others, contact your healthcare provider for advice.

When using Humalog (Insulin Lispro), it's crucial to be aware of potential interactions with other medications or supplements. Always inform your doctor and pharmacist about any drugs or supplements you are taking, whether they are prescription, over-the-counter, vitamins, or herbal products.

Important Drug Interactions

1. Beta-blockers: Medications like metoprolol, Propranolol, and Timolol (used in glaucoma eye drops) can mask the rapid heartbeat that usually signals low blood sugar (hypoglycemia). However, other symptoms such as dizziness, hunger, or sweating remain unaffected. It's important to monitor your blood sugar levels regularly and discuss any concerns with your doctor, who may adjust your diabetes medication, diet, or exercise plan accordingly.

2. Insulin Lispro and Insulin Lispro-aabc: These two forms of insulin are very similar, and using them together is not recommended. Ensure you are using only one type to avoid complications.

3. Other Medications: Humalog may interact with a range of medications, some of which are generally not recommended to be used together unless necessary. These include certain antibiotics (such as Ciprofloxacin and Levofloxacin), medications for diabetes (like Liraglutide and Pioglitazone), and others. Your doctor might adjust doses or usage frequency if these drugs are prescribed together.

4. Increased Side Effects: Some medications, including beta-blockers like Atenolol and Propranolol, herbal supplements like bitter melon and fenugreek, and various other drugs, may increase the risk of side effects when used with Humalog. If prescribed together, your doctor will manage your treatment to balance benefits and risks.

Always communicate with your healthcare provider before starting, stopping, or changing any medication to ensure your blood sugar levels remain stable and health risks are minimized.