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This document outlines essential safety information and warnings regarding the use of Humulin N (human insulin). It's important to thoroughly understand these risks and precautions to ensure safe usage. If you have any concerns, please consult your healthcare provider.

• Do Not Share: Never share Humulin N pens, syringes, or needles with others. Sharing can lead to serious infections and diseases.

• Hypoglycemia Risk: Using Humulin N, either alone or with other diabetes medications, may cause low blood sugar (hypoglycemia), which can be life-threatening. Symptoms include shakiness, hunger, nervousness, rapid heartbeat, sweating, confusion, weakness, fatigue, or increased sleepiness. Always have a source of sugar available to address these symptoms immediately. Risk factors include dietary changes, increased physical activity, alcohol consumption, use of other diabetes medications, being over 65 years old, and liver or kidney issues. Incorrect insulin injection can also increase risk.

• Severe Allergic Reactions: In rare cases, Humulin N can cause severe allergic reactions. Seek emergency medical help if you experience breathing difficulties, a blistering skin rash with fever, or swelling of the face, mouth, or throat.

• Low Potassium Levels: Humulin N may lower potassium levels in the blood, which can be hazardous. This risk is heightened if you are taking medications that reduce potassium, such as laxatives or diuretics. Regular monitoring of potassium levels by your healthcare provider is recommended.

• Drug Interactions: Caution is advised if you are taking Thiazolidinediones (e.g., pioglitazone, rosiglitazone) along with Humulin N, as this combination may cause fluid retention and potentially exacerbate heart failure. Your healthcare provider will monitor your condition closely.

No contraindications are listed for Humulin N.

When taking this medication, some individuals may experience mild side effects such as injection site reactions like pain, redness, or irritation, as well as weight gain. These effects are generally manageable, but if they persist or worsen, it is advisable to consult a healthcare provider. Additionally, some users may notice mild swelling in the legs or a headache.

More serious side effects, although less common, require immediate medical attention. These include severe hypoglycemia, which can manifest as symptoms such as sudden sweating, shaking, rapid heartbeat, hunger, blurred vision, dizziness, or tingling of hands and feet. If left untreated, severe hypoglycemia could lead to unconsciousness or seizures. Similarly, dangerously low potassium levels might present as muscle cramps, weakness, or an irregular heartbeat, and should be addressed promptly.

Serious allergic reactions are rare but critical to recognize. Symptoms like rash, itching, swelling of the face, lips, tongue, or throat, severe dizziness, and trouble breathing should prompt urgent medical care. It is essential to monitor for any unusual side effects and seek medical advice if any concerning symptoms arise. Regular meal schedules can help manage blood sugar levels and prevent hypoglycemia, and it is wise to carry quick sources of sugar or glucose tablets as a precaution.