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Here is vital safety and warning information regarding the use of Humulin R (insulin regular). Please review these details thoroughly and discuss any concerns with your healthcare provider.

• Infection Risk from Shared Injection Supplies: Do not share Humulin R (insulin regular) pens, syringes, or needles with others. Sharing can lead to the transmission of serious infections.

• Blood Sugar Variability with Insulin Routine Changes: Altering your insulin regimen, such as changing the injection site or switching brands, can impact how your body processes insulin, potentially causing high or low blood sugar levels. Repeated injections in areas with lipodystrophy can also result in high blood sugar.

• Hypoglycemia (Dangerously Low Blood Sugar): Using Humulin R alone or with other blood sugar-lowering medications can cause hypoglycemia, a severe condition that can be life-threatening if not promptly addressed. Risks include dietary and exercise changes, alcohol consumption, concurrent diabetes medications, and liver or kidney issues.

• Hypokalemia (Low Blood Potassium): Humulin R may lead to low potassium levels, especially if you are also taking medications like loop diuretics. Since hypokalemia often has no symptoms, regular blood tests may be necessary. Seek immediate medical attention if you experience weakness, muscle cramps, or constipation.

• Fluid Retention and Heart Failure: Combining Humulin R with glitazones (thiazolidinediones) can cause fluid retention, worsening heart failure symptoms such as difficulty breathing, swelling, and fatigue.

• Severe Allergic Reactions: Though rare, Humulin R can provoke serious allergic reactions, including anaphylaxis. If you notice swelling of the lips, face, or tongue, rash, or difficulty breathing, seek emergency medical help.

Contraindications: Do not use Humulin R during episodes of low blood sugar (hypoglycemia), as it may exacerbate the condition. Always consult your healthcare provider if you have concerns about starting this medication.

When using this medication, some common side effects may include reactions at the injection site, such as pain, redness, or itching, along with potential weight gain. These effects are usually mild but should be monitored. If they persist or worsen, it is advisable to consult your healthcare provider for guidance.

Low blood sugar (hypoglycemia) is another possible side effect. Symptoms can include sudden sweating, shaking, a fast heartbeat, hunger, blurred vision, dizziness, or tingling in the hands and feet. To manage these symptoms, it is wise to carry glucose tablets or gel, or consume a quick source of sugar like candy or fruit juice if necessary. Regular meal schedules can help prevent hypoglycemia. On the other hand, high blood sugar (hyperglycemia) may lead to increased thirst or frequent urination. Any such symptoms should be promptly discussed with your healthcare provider.

There are also more severe side effects to be aware of. Although rare, significantly low potassium levels can manifest as muscle cramps, weakness, or an irregular heartbeat, while severely low blood sugar could cause faintness, confusion, or extreme hunger. In such cases, seek immediate medical attention. Additionally, a serious allergic reaction, though infrequent, may occur. Symptoms to watch for include rash, severe dizziness, swelling of the face, tongue, or throat, and difficulty breathing. Immediate medical care is essential if these symptoms arise. Always be vigilant for any unusual effects and consult your healthcare provider if they occur.

Beta-blockers, including medications like metoprolol, Propranolol, and Timolol (used in some glaucoma eye drops), can mask the rapid or pounding heartbeat that often signals low blood sugar (hypoglycemia). However, they do not affect other symptoms of low blood sugar, such as dizziness, hunger, or sweating. Additionally, many medications can influence your blood sugar levels, complicating the management of your diabetes. It's important to consult with your doctor or pharmacist before starting, stopping, or changing any medication, as these actions might impact your blood sugar control. Regularly monitor your blood sugar as advised by your healthcare provider and report any symptoms of high or low blood sugar to your doctor. Your healthcare provider might need to adjust your diabetes medications, exercise routine, or diet based on these interactions.

Humulin R (insulin regular) can interact with various medications or supplements. It is crucial to inform your doctor and pharmacist about all the medications and supplements you are currently taking, including prescriptions, over-the-counter drugs, vitamins, and herbal products. The following beta-blockers might increase the likelihood of certain side effects when used with Humulin R: Acebutolol, Atenolol, Betaxolol, Bisoprolol, Carteolol, Carvedilol, celiprolol, esmolol, Labetalol, Levobunolol, metipranolol, metoprolol, Nadolol, Nebivolol, oxprenolol, penbutolol, Pindolol, practolol, propranolol, Sotalol, and timolol. If your doctor prescribes both Humulin R and any of these beta-blockers, they may need to adjust the dose or frequency of one or both medications to ensure safe and effective treatment.