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This medication carries significant safety warnings that are essential to consider before use. Please review the following information carefully and consult your healthcare provider if you have any questions or concerns.

• Pregnancy Warning: This drug can lead to serious, potentially fatal harm to an unborn child if taken during pregnancy. It is crucial to avoid pregnancy while using this medication. Speak with your doctor about effective birth control methods. If you are pregnant, planning to become pregnant, or suspect you might be pregnant, contact your healthcare provider immediately.

• Low Blood Pressure: The use of Hyzaar (losartan / hydrochlorothiazide) may result in a significant drop in blood pressure, causing dizziness, fatigue, or lightheadedness. These symptoms are more likely when starting the medication or increasing the dose. Stay hydrated to help manage this risk. If you experience severe dizziness or fainting, sit down slowly and contact your provider. Seek immediate medical attention if you fall and injure yourself. Report symptoms such as dizziness, confusion, or fatigue to your healthcare provider promptly.

• Kidney Function: Hyzaar can impact kidney health, particularly in individuals with existing kidney issues or severe heart failure. Regular lab tests may be necessary to monitor kidney function. Notify your provider if you notice a decrease in urination, as this can indicate kidney problems. Consult your healthcare provider if you have a history of renal artery stenosis, severe heart failure, or other conditions that may affect your kidneys.

• Electrolyte, Blood Sugar, and Cholesterol Changes: This medication can alter the levels of sodium, potassium, and magnesium in your body. Regular blood tests may be required to ensure electrolyte levels remain stable. Symptoms like rapid heartbeat, weakness, fatigue, muscle pain, decreased urination, nausea, or vomiting should be reported to your doctor immediately, as they may signal electrolyte imbalances.

• Vision Changes: Rarely, vision changes can occur shortly after starting Hyzaar due to its hydrochlorothiazide component. Immediate medical consultation is necessary if you experience any changes in vision or eye pain. In severe cases, surgery might be needed to prevent permanent vision loss. Individuals with sulfa or penicillin allergies may be at increased risk.

• Lupus Worsening: Hyzaar can rarely exacerbate lupus symptoms or cause new onset lupus. Notify your healthcare provider if you develop a rash across your cheeks and nose or experience extreme fatigue.

Contraindications:

• Do not use this medication if you are unable to produce urine.
• Avoid concurrent use with aliskiren (Tekturna) if you have diabetes, as it may pose additional health risks.

Always consult with your healthcare provider to ensure this medication is safe for your use, particularly if you have any pre-existing health conditions.

When taking this medication, you may experience common side effects such as dizziness, upper respiratory tract infections like the common cold, and back pain. These are generally mild and should not be a cause for alarm; however, if they persist or worsen, it's advisable to contact your healthcare provider. Other side effects that might occur include headaches, trouble sleeping, rashes, and stomach upset. Again, these are usually not serious but should be monitored if they become bothersome.

There are, however, more serious side effects that require immediate medical attention. These include signs of dangerously low blood pressure, such as dizziness, lightheadedness, and feeling faint, as well as symptoms of serious kidney problems like reduced urination, swelling in your extremities, and unexplained weight gain. An increase in blood potassium levels can also occur, leading to nausea, muscle weakness, and an abnormal heartbeat. Additionally, although rare, severe allergic reactions can manifest as swelling of the lips, tongue, throat, or face along with trouble breathing, and these symptoms necessitate urgent medical care.

Be aware that this medication can cause dehydration and electrolyte imbalance, so it's important to watch for symptoms such as unusual dry mouth, thirst, muscle cramps or weakness, irregular heartbeat, or confusion. Although a very serious allergic reaction is rare, seek medical help immediately if you notice symptoms like a rash or severe dizziness. Always consult your healthcare provider if you experience any unexpected effects.

When taking Hyzaar (losartan/hydrochlorothiazide), it's important to be aware of potential interactions with other medications and supplements. Inform your healthcare provider about any other drugs or supplements you are using, whether they are prescription, over-the-counter, vitamins, or herbal products, to ensure safe use.

Some medications should not be combined with Hyzaar, such as Aliskiren and Dofetilide, due to an increased risk of adverse effects. Your doctor may advise against using these together or adjust your treatment plan.

Other drugs, like ACE inhibitors (e.g., Benazepril, Lisinopril), Lithium, and certain birth control pills containing drospirenone, can increase potassium levels in your blood. In some cases, using these medications with Hyzaar might still be necessary, but your doctor may need to modify dosages or monitor your therapy closely.

Additionally, some over-the-counter products, such as NSAIDs (e.g., Ibuprofen, Naproxen), cough-and-cold remedies, and diet aids, can raise blood pressure or exacerbate heart failure. Always discuss these with your pharmacist to understand the safest way to use them.

Lastly, Hyzaar may interfere with specific laboratory tests, like those measuring parathyroid function, potentially leading to incorrect results. Ensure all healthcare professionals involved in your care are aware that you are taking this medication.