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The safety information outlined below highlights crucial warnings and precautions for the use of lansoprazole (Prevacid). It's essential to review these details and consult your healthcare provider if you have any concerns or questions.

• Symptom Masking: Persistent or worsening heartburn may indicate a more severe condition, such as stomach cancer. Notify your healthcare provider if heartburn persists or is accompanied by poor appetite, unexplained weight loss, or weakness.

• Kidney Issues: Lansoprazole and other PPIs may cause sudden kidney problems at any stage of treatment. Seek medical advice if you experience unusual changes in urination, nausea, weakness, fever, rash, or joint pain.

• Severe Diarrhea Risk: The use of PPIs can increase the likelihood of Clostridioides difficile infection, especially in individuals over 65, those recently in healthcare facilities, or with weakened immune systems. Report severe or watery diarrhea, fever, abdominal pain, appetite loss, or nausea to your provider immediately.

• Bone Fractures: Long-term or high-dose use of lansoprazole can elevate the risk of fractures in the hip, wrist, or spine. Discuss your risk factors with your healthcare provider, particularly if you have a history of fractures or osteoporosis.

• Serious Skin Reactions: Rare skin reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis, have been reported. Immediate medical attention is required if you notice symptoms such as fever, body aches, rash, blistering, or facial swelling.

• Lupus: Some individuals may experience new or aggravated lupus symptoms, such as joint pain or rash, which usually improve after stopping the medication. Contact your provider if these symptoms occur.

• Vitamin and Mineral Deficiencies: Prolonged use of lansoprazole may lead to low vitamin B12 and magnesium levels. If you have been on this medication for over three years or exhibit symptoms of deficiency, consult your healthcare provider.

• Drug Interactions: Certain medications may interfere with lansoprazole's effectiveness and safety. Avoid using St. John’s Wort and rifampin as they can reduce the drug's efficiency.

• Phenylketonuria (PKU) Consideration: Orally disintegrating tablets of lansoprazole contain phenylalanine, which is unsafe for individuals with PKU. Use the capsule form instead and consult your provider to ensure safe options.

Contraindications include:

• Known allergy to PPIs.
• Concurrent use of Edurant (rilpivirine) or rilpivirine-containing products like Complera.

Always consult your healthcare provider for personalized advice and guidance regarding the use of lansoprazole.

Common side effects:

• Diarrhea
• Abdominal pain
• Headaches
• Nausea
• Constipation

Serious side effects:

• Severe stomach pain
• Persistent diarrhea
• Muscle spasms
• Irregular heartbeat
• Seizures
• Signs of kidney problems
• Lupus symptoms (rash on cheeks or nose and joint pain)
• Vitamin B-12 deficiency symptoms (unusual weakness, sore tongue, numbness and tingling in hands or feet)
• Serious allergic reactions (fever, swollen lymph nodes, severe rash, difficulty breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• Rilpivirine
• Dexlansoprazole

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Methotrexate
• Acalabrutinib
• Amphetamine
• Atazanavir
• Benzphetamine
• Bosutinib
• Capecitabine
• Cilostazol
• Citalopram
• Clopidogrel
• Dacomitinib
• Dasatinib
• Delavirdine
• Dextroamphetamine
• Erlotinib
• EslicarbazepineAcetate
• Gefitinib
• Ketoconazole
• Ledipasvir
• Lisdexamfetamine
• Methamphetamine
• MycophenolateMofetil
• Nelfinavir
• Neratinib
• Nilotinib
• Octreotide
• Pazopanib
• Pexidartinib
• Saquinavir
• Secretin Human
• Selpercatinib
• Sunitinib
• Velpatasvir
• Vismodegib
• Voriconazole

Interactions with low risk that usually do not require a change in therapy:

• Acenocoumarol
• Dicumarol
• Levothyroxine
• Phenprocoumon
• Tacrolimus
• Warfarin