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This medication comes with several important safety warnings that need careful consideration. You should discuss any concerns with your healthcare provider to ensure safe use.

• Risk of Masking Serious Conditions: Persistent heartburn could indicate stomach cancer. If heartburn worsens or returns after taking lansoprazole (Prevacid), or if you experience poor appetite, unexplained weight loss, or weakness, contact your healthcare provider to rule out more serious medical issues.

• Sudden Kidney Problems: Some users of PPIs, including lansoprazole (Prevacid), have experienced sudden kidney issues at any point during treatment. Symptoms such as changes in urination, nausea, weakness, fever, rash, or joint pain should be discussed with your provider.

• Severe Infectious Diarrhea: Lansoprazole (Prevacid) may increase the risk of Clostridioides difficile (C. diff) infection, leading to severe diarrhea. This risk is heightened for individuals over 65, those recently hospitalized or in nursing homes, or with weakened immune systems. Use the lowest effective dose for the shortest time, and contact your provider if you experience severe diarrhea, fever, abdominal pain, or nausea.

• Bone Fractures: Long-term or high-dose use of lansoprazole (Prevacid) can increase fracture risks in the hip, wrist, or spine, especially if taken for more than a year. Discuss with your provider if you have a history of fractures or osteoporosis.

• Skin Reactions: Rare but serious skin reactions such as Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) have been reported. Seek immediate medical attention if you notice symptoms like fever, body aches, rash, or blistering.

• Lupus: Some individuals have developed or experienced worsening lupus symptoms while on PPIs like lansoprazole (Prevacid). Joint pain or rash symptoms should prompt you to discontinue the medication and consult your provider.

• Low Vitamin B12 and Magnesium Levels: Long-term use can lead to deficiencies in vitamin B12 and magnesium. If you have been using this medication for over 3 years or notice symptoms such as dizziness, muscle weakness, or tingling, contact your provider.

• Drug Interactions: Certain drugs may affect lansoprazole (Prevacid) levels in your body, altering its effectiveness and the risk of side effects. Avoid medications like St. John’s Wort and rifampin while taking this medication.

• Phenylketonuria (PKU) Caution: Orally disintegrating tablets contain phenylalanine, which can be harmful to individuals with PKU. Consider using the capsule form, which is safer for those with PKU, and consult your provider if unsure.

Contraindications:

• Do not use if you have a history of allergy to PPIs.
• Avoid if you are taking Edurant (rilpivirine) or rilpivirine-containing medications (e.g., Complera).

In case of an overdose, seek emergency medical attention promptly. Always adhere to your healthcare provider’s instructions for safe use.

When taking this medication, some individuals may experience mild side effects such as diarrhea, abdominal pain, nausea, or constipation. These are generally not serious and often resolve on their own. However, if these symptoms persist or worsen, it is advisable to consult your healthcare provider for further guidance.

More serious side effects, although rare, require prompt medical attention. These can include severe stomach pain or diarrhea, which might indicate a bacterial infection called C. difficile. Symptoms like joint pain, a skin rash exacerbated by sunlight, or changes in urination could be signs of lupus or kidney problems, respectively. Additionally, be aware of symptoms signaling a low magnesium level, such as muscle spasms, irregular heartbeat, or seizures.

Long-term use of this medication, particularly proton pump inhibitors like lansoprazole, may lead to vitamin B-12 deficiency, manifesting as unusual weakness, a sore tongue, or numbness in the hands and feet. In rare cases, a serious allergic reaction may occur, presenting with fever, swollen lymph nodes, or difficulty breathing. Immediate medical attention is crucial if these severe symptoms arise. Always stay vigilant and report any unusual side effects to your healthcare provider for appropriate management.

When taking lansoprazole, it is important to be aware of potential interactions with other medications. Specifically, avoid using Methotrexate, especially in high doses, as it may interact with lansoprazole. Lansoprazole reduces stomach acid, which can affect the absorption and effectiveness of certain medications such as Ampicillin, Atazanavir, Erlotinib, levoketoconazole, nelfinavir, pazopanib, rilpivirine, sparsentan, and some azole antifungals like Itraconazole, Ketoconazole, and Posaconazole. Additionally, lansoprazole is similar to Dexlansoprazole, so do not use them together.

Lansoprazole may also impact the accuracy of certain lab tests, so inform your healthcare providers and lab personnel about its use.

Moreover, lansoprazole should not be combined with rilpivirine. With some medications, such as acalabrutinib, amphetamine, atazanavir, and others listed, its use is usually not recommended unless necessary. In such cases, your doctor might adjust the dosage or frequency of either medication. Additionally, lansoprazole may increase the risk of side effects with medications like acenocoumarol, dicumarol, Levothyroxine, phenprocoumon, Tacrolimus, and Warfarin, so your doctor may need to monitor and adjust treatment accordingly. Always inform your doctor and pharmacist about all medications and supplements you are taking to avoid unwanted interactions.