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Here is important safety and warning information for the medication dexlansoprazole (Dexilant). Please review these details carefully and consult your healthcare provider if you have any questions or concerns.

• Potential Masking of Serious Conditions: Recurrent heartburn could signal a more serious condition like stomach cancer. If heartburn worsens or recurs after starting dexlansoprazole, or if you experience a poor appetite, unexplained weight loss, or weakness, contact your healthcare provider.

• Sudden Kidney Issues: There have been reports of abrupt kidney problems in some individuals using proton pump inhibitors (PPIs) like dexlansoprazole. Symptoms such as changes in urination, nausea, weakness, fever, rash, or joint pain should prompt immediate consultation with a healthcare provider.

• Severe Infectious Diarrhea: Dexlansoprazole may increase the risk of Clostridioides difficile (C. diff) infection, leading to severe diarrhea. This risk is heightened in individuals over 65, those with recent hospital or nursing home stays, or those with weakened immune systems. If severe diarrhea, fever, abdominal pain, loss of appetite, or nausea occurs, seek medical advice promptly.

• Bone Fracture Risk: Long-term or high-dose use of dexlansoprazole can elevate the risk of fractures in the hip, wrist, or spine, particularly in older adults. Discuss your fracture risk with your healthcare provider, especially if you have a history of fractures or osteoporosis.

• Serious Skin Reactions: Although rare, serious skin reactions like Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) have been associated with PPIs. Symptoms include fever, body aches, rash, peeling skin, blisters, and facial swelling. Immediate medical attention is necessary if these occur.

• Lupus Erythematosus: Some individuals using PPIs have experienced new or worsening lupus symptoms. If joint pain or rash arises, discontinue use and contact your healthcare provider.

• Vitamin and Mineral Deficiencies: Long-term use of dexlansoprazole may lead to decreased vitamin B12 or magnesium levels. If you experience symptoms of deficiency, such as dizziness, muscle weakness, pale skin, fatigue, or tingling in limbs, contact your doctor.

• Drug Interactions: Certain medications may affect how dexlansoprazole is processed in your body. Drugs like St. John’s Wort and rifampin may decrease its effectiveness. Avoid these medications while taking dexlansoprazole.

• Contraindications: This medication should not be used in combination with medications containing rilpivirine, such as Edurant or Cabenuva, due to potential serious health risks. Consult your healthcare provider if you are taking these or similar medications.

In case of any adverse reactions or concerns, please consult your healthcare provider for guidance.

Common side effects:

• Diarrhea
• Belly pain
• Nausea
• Headache
• Common cold symptoms
• Mouth or throat pain

Less common but important to monitor:

• Persistent diarrhea
• Abdominal pain
• Blood/mucus in stool
• Vitamin B-12 deficiency

Serious side effects:

• Low magnesium blood level (muscle spasms, irregular heartbeat, seizures)
• Symptoms of lupus (rash on the nose and cheeks, joint pain)
• Kidney problems (changes in urine output, pink/bloody urine)
• Very serious allergic reactions (fever, swollen lymph nodes, rash, itching or swelling of the face, tongue, or throat, severe dizziness, difficulty breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• Rilpivirine

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Methotrexate (especially high-dose treatment)
• Ampicillin
• Atazanavir
• Erlotinib
• Levoketoconazole
• Nelfinavir
• Pazopanib
• Itraconazole
• Ketoconazole
• Posaconazole
• Acalabrutinib
• Amphetamine
• Benzphetamine
• Bosutinib
• Capecitabine
• Dacomitinib
• Dasatinib
• Dextroamphetamine
• Gefitinib
• Ledipasvir
• Lisdexamfetamine
• Methamphetamine
• Mycophenolate mofetil
• Neratinib
• Nilotinib
• Octreotide
• Pexidartinib
• Saquinavir
• Secretin Human
• Selpercatinib
• Sunitinib
• Velpatasvir
• Vismodegib

Interactions with low risk that usually do not require a change in therapy:

• Levothyroxine
• Warfarin