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This document outlines important safety information regarding the use of Hyoscyamine. It is crucial to understand the potential risks, precautions, and contraindications associated with this medication. Always consult your healthcare provider if you have any questions or concerns.

• Dizziness and Impaired Attention: Hyoscyamine may cause drowsiness, dizziness, and blurred vision. Avoid driving or engaging in activities that require full attention until you are aware of how this medication affects you.

• Mood and Cognitive Changes: The medication can alter mood, thoughts, and cognitive abilities, leading to symptoms such as confusion, memory issues, disorientation, agitation, hallucinations, or euphoria. In severe instances, it may result in coma. These effects typically resolve within 12 to 48 hours after discontinuation. Notify your healthcare provider immediately if you experience any mood or cognitive changes. Those over 65 or with mental health conditions are at higher risk.

• Increased Heart Rate: Inform your provider if you have heart conditions, including heart failure, prior heart attacks, or hypertension, as Hyoscyamine can elevate heart rate, potentially exacerbating these issues. Report any symptoms like palpitations or a racing heart.

• Altered Bodily Functions: This medication can affect the autonomic nervous system, leading to slowed gut movement, constipation, dry mouth, reduced saliva or sweat production, and increased risk of heat stroke. It may also impact heart rate and vision. If you have a fever, consult your provider before use. Those over 65 should exercise additional caution.

• Urinary Difficulties: Use Hyoscyamine with caution if you have prostate-related issues, as it may aggravate these conditions and cause urination difficulties.

• Gut-Related Precautions: If you have undergone procedures like a colostomy, consult your provider before using Hyoscyamine for diarrhea, as it could indicate a bowel obstruction, which the medication might worsen.

Contraindications

Do not use Hyoscyamine if you have the following conditions, as it may lead to serious health consequences:

• Glaucoma
• Urinary tract blockage
• Stomach or intestinal blockage
• Chronic constipation
• Unstable cardiovascular or bleeding issues
• Severe ulcerative colitis with toxic megacolon
• Myasthenia gravis

Ensure to discuss with your healthcare provider before starting Hyoscyamine if any of these conditions apply to you.

Common side effects:

• Dry mouth
• Trouble urinating
• Constipation
• Blurry vision
• Dry eyes
• Sleepiness
• Dizziness
• Headache
• Flushing
• Heat intolerance

Less common but important to monitor:

• Fast heart rate
• Diarrhea
• Confusion
• Short-term memory loss

Serious side effects:

• Severe mood changes
• Psychosis
• Agitation
• Hallucinations
• Confusion
• Euphoria
• Irregular heartbeat
• Fainting
• Dizziness
• Chest discomfort
• Shortness of breath
• Fatigue

When taking Levsin SL, it's important to be aware of potential interactions with other medications and substances. Combining Levsin SL with certain drugs can enhance side effects such as drowsiness, blurred vision, dry mouth, decreased sweating, difficulty urinating, constipation, rapid heartbeat, confusion, and memory problems. These effects may be more pronounced in older adults or those with existing health conditions.

Specifically, using Levsin SL alongside other anticholinergic medications—including Amantadine, Haloperidol, phenothiazines, monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants, and some antihistamines—can lead to additive adverse effects due to increased cholinergic blockade. Additionally, antacids may interfere with the absorption of Levsin SL; therefore, it's recommended to take Levsin SL before meals and antacids after meals.

Alcohol consumption while on Levsin SL can also increase drowsiness and dizziness. It's advisable to avoid or limit alcohol intake and to refrain from activities requiring mental alertness, such as driving, until you know how the medication affects you.

Always inform your healthcare provider about all medications, supplements, and over-the-counter drugs you are taking to ensure safe and effective use of Levsin SL.