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This document contains crucial safety information regarding the use of topical hydrocortisone. It is important to carefully review the following details and consult your healthcare provider with any questions or concerns.

• Hormone Issues and Withdrawal: Extended use of topical hydrocortisone over large skin areas can occasionally lead to adrenal suppression, a condition where the body reduces its steroid hormone production. Abrupt cessation of the medication may cause withdrawal symptoms such as skin swelling, rash, and burning. To mitigate this, healthcare providers will prescribe the lowest effective dose for the shortest duration. If prolonged use is necessary, periodic lab tests might be required to monitor adrenal function. Do not discontinue use suddenly; always consult with your healthcare provider first. Risks are higher if used excessively, on large areas, or if covered with a bandage, particularly for young children.

• Elevated Blood Sugar: Prolonged or extensive use of topical hydrocortisone may increase blood sugar levels, potentially leading to diabetes. Patients with diabetes should regularly monitor their blood sugar levels while using this medication. Inform your healthcare provider if you experience increased thirst or urination. Risks are associated with long-term or excessive use.

• Infections: Long-term use of topical hydrocortisone may increase the risk of developing skin or oral infections, including fungal or bacterial types. Avoid using it if you have an active skin infection, as it may exacerbate the condition. Contact your healthcare provider if you notice redness, swelling, pain, pus, or no improvement in symptoms after seven days, as these may indicate a new infection. The risk increases with use beyond seven days.

• Skin Reactions: Using topical hydrocortisone longer than advised can lead to skin reactions such as thinning, stretch marks, spider veins, burning, itching, irritation, dryness, inflamed hair follicles, changes in skin color, or rashes. To prevent severe reactions, use the lowest effective dose for the briefest period. Promptly inform your healthcare provider of any new or worsening skin issues. Risks are heightened with excessive or inappropriate use.

There are no contraindications available for this medication. Always follow your healthcare provider's guidance for safe use.

When using this medication, some individuals may experience common side effects such as stinging, burning, itching, irritation, dryness, or redness at the application site. These mild effects often subside as your body becomes accustomed to the treatment. If they persist or worsen, it's advisable to consult with a healthcare professional.

Occasionally, users may notice more noticeable effects including inflamed hair follicles, acne-like bumps, changes in skin color, or increased hair growth. Stretch marks, thinning skin, or skin pruning may also occur. Although these effects are less common, it is important to seek medical advice if they become bothersome or severe.

In rare cases, the medication may be absorbed into the bloodstream, leading to symptoms like unusual fatigue, weight loss, headaches, swelling of the ankles or feet, increased thirst or urination, and vision problems. These symptoms are more likely in children or when the medication is used extensively over large skin areas. Immediate medical attention is crucial if such symptoms develop.

Severe allergic reactions are extremely rare but require urgent medical care. Symptoms can include rash, itching or swelling, particularly of the face, tongue, or throat, severe dizziness, or difficulty breathing. If you experience any unusual effects not listed, consulting a healthcare provider is recommended.