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This document outlines crucial safety information and warnings related to the use of Lomotil (diphenoxylate/atropine). It is important to carefully review these details and discuss any concerns with your healthcare provider.

• Breathing Issues: Lomotil can cause severe breathing problems or coma, especially in children, potentially leading to permanent brain damage or death. The highest risk is for children under 6 years old. Ensure the medication is stored securely and out of reach of children. Be cautious if you are taking other medications that can affect breathing.

• Drowsiness and Dizziness: This medication may induce sleepiness or dizziness, impairing focus, cognition, and reaction times. Avoid alcohol and other sedatives like benzodiazepines, muscle relaxants, and opioids, which can amplify these effects. Refrain from driving or operating machinery until you understand how Lomotil affects you.

• Dehydration: Diarrhea can lead to dehydration. It is essential to stay hydrated while experiencing diarrhea and when using Lomotil. If you have concerns about fluid intake, consult your pharmacist or healthcare provider.

• Severe Bowel Complications: Lomotil may cause serious bowel issues and should not be used for diarrhea caused by bacterial infections, as it slows intestinal movement and can promote bacterial growth. If symptoms worsen after taking Lomotil, contact your healthcare provider.

Contraindications: Do not use Lomotil if you are:

• A child under 6 years old.
• Experiencing diarrhea caused by a bacterial infection.

Please consult your healthcare provider if any of these warnings or contraindications apply to you.

When taking this medication, some common side effects you might experience include drowsiness, dizziness, headache, tiredness, and blurred vision. These effects are usually mild and often resolve on their own. However, if they persist or worsen, it's important to contact your healthcare provider. You may also notice a dry mouth or a reduced appetite, which are similarly common and typically not a cause for concern.

Less frequently, some individuals might experience nausea, vomiting, or mild restlessness. Additionally, dry skin or feelings of confusion could occur. While these effects can be uncomfortable, they are not typically serious. Nonetheless, discussing them with your healthcare provider is advisable, especially if they are bothersome.

On the more serious side, there are rare side effects that require immediate medical attention. If you experience severe stomach or abdominal pain, swelling, or significant mood changes such as depression or unusual restlessness, seek care promptly. Numbness or tingling in the arms or legs, or vision changes like seeing rainbows around lights at night, should also be addressed urgently.

Very serious reactions are uncommon but can include eye pain or swelling, severe dizziness, or trouble breathing. An allergic reaction, although rare, may present as a rash, itching, swelling, or difficulty breathing and necessitates immediate medical help. Always inform your healthcare provider if you experience any side effects, even those not listed here, as this can help ensure your safety while using the medication.

When taking Lomotil (diphenoxylate/atropine), it's important to be aware of potential interactions with other medications. Inform your doctor or pharmacist about all the medications and supplements you are currently using, including prescription, over-the-counter, vitamins, and herbal products.

Certain medications should not be combined with Lomotil. These include Ambenonium, Nalmefene, Naltrexone, Potassium supplements, and Safinamide. In such cases, your doctor might opt to avoid prescribing Lomotil or adjust the medications you take.

There are medications that are generally not recommended to use alongside Lomotil, although sometimes it may be necessary. In such instances, your healthcare provider may modify the dosages or frequency of use. These medications include, but are not limited to, Alfentanil, Alprazolam, Amifampridine, Benzhydrocodone, Buprenorphine, Cetirizine, Codeine, Hydrocodone, Isocarboxazid, Linezolid, Lorazepam, Methadone, Naltrexone, Phenelzine, Safinamide, Selegiline, Tranylcypromine, and Zolpidem.

Additionally, using Lomotil with other drugs that cause drowsiness, such as opioid pain or cough relievers (e.g., codeine, hydrocodone), alcohol, marijuana (cannabis), sleep or anxiety medications (e.g., alprazolam, lorazepam, zolpidem), muscle relaxants (e.g., Carisoprodol, Cyclobenzaprine), or antihistamines (e.g., cetirizine, diphenhydramine), may increase drowsiness. Always check your medication labels for ingredients that may cause drowsiness and consult your pharmacist for safe use.

Lastly, some combinations might increase the risk of side effects, and your doctor may adjust your treatment plan accordingly. Always follow your healthcare provider’s instructions closely to ensure your safety.