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Estrogens, whether taken alone or combined with another hormone such as progestin, have been known to cause serious side effects in rare cases. It is essential to have a thorough discussion with your healthcare provider about the risks and benefits of hormone therapy. Estrogens should not be used as a preventive measure against heart disease or dementia.

• Cancer Risks: Use of estrogens can increase the risk of uterine (endometrial) cancer. To help mitigate this risk, follow your doctor's guidance on taking progestin. Report any unusual vaginal bleeding to your doctor immediately.

• Additional Risks for Postmenopausal Women: In postmenopausal women, estrogen use, with or without progestin, heightens the risk of breast and ovarian cancer, strokes, dementia, and severe blood clots. When combined with progestin, there is also an increased risk of heart disease, including heart attacks.

• Dosage and Duration: The likelihood of severe side effects may be influenced by the dose and duration of estrogen use. It is recommended to use the lowest effective dose for the shortest duration necessary. Regular consultations with your healthcare provider, approximately every 3 to 6 months, are advised to reassess the necessity of continued treatment.

• Long-term Use: If long-term use is required, ensure you have comprehensive physical examinations annually or as directed by your healthcare provider.

Please follow these guidelines closely and maintain open communication with your doctor regarding any concerns or changes in your health.

You might experience mild side effects such as skin redness or irritation at the application site, nausea, vomiting, bloating, breast tenderness, headaches, or changes in weight. These are generally not serious, but if they persist or worsen, it's important to consult a healthcare professional.

There are some more serious side effects to be aware of. If you experience persistent nausea or vomiting, mood or mental changes like depression or memory loss, breast lumps, unusual vaginal bleeding, increased or new vaginal irritation or discharge, severe stomach or abdominal pain, yellowing of the eyes or skin, dark urine, swelling in the hands, ankles, or feet, or increased thirst and urination, seek medical attention promptly.

Rarely, this medication can lead to serious blood clot issues, which can be life-threatening. If you notice symptoms such as chest, jaw, or left arm pain, unusual sweating, sudden severe headaches, weakness on one side of the body, confusion, difficulty speaking, sudden vision changes, pain or swelling in the groin or calf, shortness of breath, rapid breathing, sudden dizziness, or fainting, get emergency medical help immediately.

Severe allergic reactions to this medication are rare but require urgent medical attention. Symptoms include rash, itching or swelling, especially of the face, tongue, or throat, severe dizziness, and trouble breathing. If you encounter side effects not mentioned here, contact a healthcare provider for guidance.