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The following safety and warning information for Lynparza (olaparib) is crucial for understanding the potential risks associated with its use. It is important to discuss any concerns with your healthcare provider.

• Bone Marrow and Cancer Risks: There is a rare risk of developing myelodysplastic syndrome (MDS) or new blood cancers, which can be fatal. These conditions have been observed in individuals who have been on Lynparza (olaparib) anywhere from less than six months to over ten years, especially those previously treated with radiation or platinum-based chemotherapy. Regular blood tests will be conducted before and monthly during treatment to monitor for these risks. Discuss any concerns about cancer risks with your healthcare provider.

• Lung Issues: Some patients have experienced lung problems, such as pneumonitis, which can occasionally be life-threatening. Immediately report any new or worsening cough, shortness of breath, or fever to your healthcare provider. Treatment may be paused while your lungs are assessed.

• Blood Clots: Lynparza (olaparib) has been associated with serious blood clots, including pulmonary embolism (PE) and deep vein thrombosis (DVT). Seek emergency medical attention if you experience symptoms like swelling, difficulty breathing, chest pain, one-sided body weakness, or speech difficulties. If a blood clot develops, your provider will likely prescribe a blood thinner.

• Risk to Unborn Babies: This medication can harm unborn babies. Inform your provider if you are pregnant or planning to become pregnant. Women with childbearing potential will need a pregnancy test before starting treatment and should use effective contraception during treatment and for six months after the last dose. Men with partners who can become pregnant should also use contraception during treatment and for three months after the last dose.

Please consult your healthcare provider for personalized advice and to address any questions or concerns you may have regarding the use of Lynparza (olaparib).

When taking this medication, some common side effects may include nausea, fatigue, vomiting, diarrhea, changes in taste, dizziness, and a decreased appetite. While these are generally mild, it's important to stay hydrated and rest adequately. Eating light meals can also help manage these symptoms. If any persist or worsen, consult your healthcare provider.

There are some more serious side effects to be aware of, though they are less common. These include signs of kidney issues such as changes in urine output, shortness of breath, and swelling in the extremities. Additionally, the medication may lower blood cell counts, possibly leading to anemia, increased susceptibility to infections, or easy bruising and bleeding. It's crucial to report symptoms like unusual tiredness, persistent sore throat, fever, or signs of infection to your healthcare provider promptly.

Also, be vigilant for symptoms indicating blood clots, such as sudden chest pain, rapid breathing, pain or swelling in the limbs, and sudden headaches or vision changes. These require immediate medical attention. In rare instances, an allergic reaction may occur, characterized by rash, severe dizziness, or difficulty breathing, necessitating urgent care.

Remember, this is not an exhaustive list of side effects. If you notice other unusual symptoms, it's advisable to discuss them with your healthcare provider. Always monitor your health closely and seek professional advice if needed.