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This document outlines critical safety information regarding the use of Talzenna (talazoparib). It is essential to review these details and discuss any concerns with your healthcare provider.

• Low Blood Cell Counts (Bone Marrow Suppression): Talzenna (talazoparib) may reduce the bone marrow's capacity to produce blood cells, increasing the risk of bleeding and susceptibility to infections, which can be life-threatening.

• Risk of Blood Cancers: There is a rare possibility of developing blood cancers while using Talzenna (talazoparib), particularly for individuals with prior treatments involving platinum-based chemotherapy or radiation. Healthcare providers will verify normal blood cell counts before initiating treatment and continuously monitor for any indications of new cancers during therapy. Discuss your risk factors with your healthcare provider.

• Potential Harm to Unborn Babies: Talzenna (talazoparib) has demonstrated potential harm to unborn children in animal studies. If you are pregnant or planning to become pregnant, inform your healthcare provider. Women who can conceive should use reliable contraception during treatment and for at least 7 months after the final dose. Men with partners who can conceive should use effective contraception, such as condoms, during treatment and for a minimum of 4 months post-treatment.

When taking this medication, you may encounter some common side effects, which are generally mild. These include nausea, vomiting, diarrhea, decreased appetite, headache, dizziness, changes in taste, and temporary hair loss. Tiredness and fatigue are also frequently reported. These symptoms usually subside over time, but if they persist or worsen, it's advisable to reach out to your healthcare provider for guidance. Temporary hair loss is another possibility, with normal hair growth typically resuming post-treatment.

More serious side effects, though rare, require immediate medical attention. These include severe allergic reactions characterized by rash, itching or swelling, severe dizziness, and difficulty breathing. Additionally, the medication can significantly reduce blood cell counts, leading to anemia, increased risk of infections, and easy bruising or bleeding. In extreme cases, this might indicate severe conditions like myelodysplastic syndrome or acute myeloid leukemia, especially in individuals with prior radiation or chemotherapy exposure. Signs to watch for include unusual weakness, weight loss, persistent sore throat, fever, chills, and pale skin.

Liver stress as indicated by blood tests and high blood sugar levels have been noted in some patients. If you notice any symptoms not listed here or experience severe side effects, contacting your healthcare provider is crucial for appropriate medical advice and intervention.