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This drug safety and warning information highlights crucial considerations you should be aware of when using this medication. Please review these points carefully and consult your healthcare provider if you have any questions or concerns.

• Medication Interactions: Inform your healthcare provider or pharmacist about all medications and supplements you are currently taking prior to starting norethindrone. They will assess potential interactions with your existing medications.

• Ectopic Pregnancy or Ovarian Cyst: There is a slight risk of an ectopic pregnancy if you become pregnant while using norethindrone. This condition, where the pregnancy occurs outside the uterus, can be serious. Seek immediate medical attention if you experience symptoms such as cramping or pain in the lower abdomen or shoulder.

• Irregular Vaginal Bleeding: Norethindrone, a progestin-only pill (POP), may cause irregular vaginal bleeding. Although usually harmless, in rare cases, it could indicate a more serious issue like an infection or cancer. Consult with your healthcare provider if you have concerns about irregular bleeding, or if you experience an absence of vaginal bleeding, to rule out pregnancy.

• Possible Risk of Cancer: Some research suggests that combination birth control pills may increase the risk of breast or ovarian cancer. It remains unclear if norethindrone or other POPs pose the same risk. Discuss any concerns regarding cancer risks with your healthcare provider.

Contraindications indicate when this medication should not be used due to serious health risks. Do not take this medication if any of the following conditions apply to you without consulting your healthcare provider:

• Pregnancy
• Confirmed or suspected breast cancer
• Undiagnosed bleeding between periods
• Liver tumor (benign or cancerous)
• Acute liver disease

This information is crucial for ensuring safe use of the medication and should be discussed with your healthcare provider to avoid any potential risks.

When taking this medication, you may experience some common side effects, which are generally mild. These include nausea, vomiting, headaches, dizziness, bloating, breast tenderness, weight gain, and vaginal bleeding between periods, often known as spotting. You might also notice irregular or missed periods. Should these effects persist or worsen, it is advisable to consult your healthcare provider for further guidance.

There are also rare, yet more severe side effects that require immediate medical attention. Be vigilant for symptoms such as lumps in the breast, significant mood changes like depression, severe stomach or abdominal pain, unusual vaginal bleeding patterns, such as continuous spotting or sudden heavy bleeding, dark urine, or yellowing of the skin or eyes. These could indicate more serious issues such as an ectopic pregnancy, characterized by severe stomach pain and spotting.

Although a very serious allergic reaction to this medication is rare, seek urgent medical help if you experience symptoms such as a rash, itching or swelling, particularly of the face, tongue, or throat, severe dizziness, or difficulty breathing. If you notice any other side effects not mentioned here, it is important to reach out to your healthcare provider promptly.