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The safety and warning information below outlines crucial considerations for those using hydroxyprogesterone. Please read carefully and discuss with your healthcare provider if you have any concerns or questions.

• Risk of Blood Clots: Hydroxyprogesterone may increase the likelihood of developing blood clots, which can have serious health implications. Key risk factors include a personal or family history of blood clots, smoking, high blood pressure, diabetes, high cholesterol, obesity, and systemic lupus erythematosus (SLE). Immediate medical attention is necessary if you experience leg or arm pain, chest pain, sudden severe headaches, trouble breathing, or abrupt changes in speech or vision.

• Increased Blood Sugar Levels: This medication can elevate blood sugar, presenting a higher risk of gestational diabetes during pregnancy. Individuals with diabetes or existing blood sugar issues should inform their healthcare provider before starting hydroxyprogesterone. More frequent monitoring of blood sugar levels may be required. Those at risk include individuals with diabetes, pre-diabetes, or metabolic syndrome.

• Fluid Retention: Hydroxyprogesterone can lead to fluid accumulation, particularly in the legs, ankles, and feet. This is more common in individuals with heart failure or kidney issues. It's important to alert your provider about any history of fluid retention or swelling. Seek medical assistance if you notice unexplained swelling, rapid weight gain, or sudden difficulty breathing.

• Allergic Reactions: Allergic responses, including severe reactions such as anaphylaxis, can occur. Symptoms like hives, rash, swelling of the lips or tongue, or trouble breathing warrant immediate medical intervention.

Contraindications: The following conditions indicate when hydroxyprogesterone should not be used due to potential health risks. Consult your healthcare provider if any of these apply:

• Current or history of blood clots.
• Known, suspected, or history of breast cancer or other hormone-sensitive cancers.
• Unexplained abnormal vaginal bleeding unrelated to pregnancy.
• Previous pregnancy loss due to missed abortion.
• Liver issues or liver tumors.

Always consult with your healthcare provider to ensure this medication is safe for you, especially if you have pre-existing conditions or other risk factors.

When taking this medication, some individuals might encounter side effects. Commonly, users report experiencing mild pain (35%) or swelling (17%) at the injection site, as well as hives (12%). These effects are generally minor, but if they persist or become bothersome, it is advisable to speak with a healthcare provider for guidance.

Other side effects include itchiness, redness at the injection site, nausea, and diarrhea. These are less common, but if they occur and cause discomfort, it's wise to consult a healthcare professional for advice.

Serious side effects, although rare, demand immediate medical attention. These include severe allergic reactions or symptoms indicative of a blood clot, such as sudden, intense pain and swelling in the limbs, chest pain, severe headaches, difficulty breathing, or sudden changes in speech or vision. If any of these symptoms are experienced, it is crucial to seek urgent medical care without delay.