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Trandolapril is a medication that requires careful consideration and awareness of potential risks and side effects. Below is important safety information and warnings associated with its use. If you have any questions or concerns, please consult your healthcare provider.

• Risk to Unborn Children: Trandolapril can cause significant harm to an unborn baby, particularly if taken during the second and third trimesters of pregnancy. Possible birth defects include a small skull, low blood pressure, and kidney failure. If you suspect you are pregnant while on this medication, contact your doctor immediately to discuss safer alternatives.

• Angioedema Warning: Trandolapril, an ACE inhibitor, can cause angioedema, a serious condition characterized by swelling of the face, throat, tongue, and internal organs. This can be life-threatening if it leads to breathing difficulties. Seek immediate medical attention if you experience facial swelling, belly pain, nausea, vomiting, or shortness of breath. Higher risk groups include Black individuals, those with a history of angioedema, and individuals taking Entresto (sacubitril/valsartan).

• Low Blood Pressure Precaution: Trandolapril may cause a significant drop in blood pressure, especially during the initial weeks of treatment or when the dose is increased. Symptoms can include dizziness, fatigue, or lightheadedness. To prevent these effects, stay hydrated and avoid sudden movements from sitting or lying positions. Notify your healthcare provider if these symptoms persist.

• Liver Concerns: Although rare, trandolapril may cause severe liver problems or liver failure, particularly in individuals with a history of liver issues. Inform your provider if you experience abdominal pain, fatigue, or yellowing of the skin or eyes.

• Kidney Function Alert: While trandolapril can benefit those with high blood pressure or chronic kidney diseases, it may worsen kidney problems in some cases. This risk is higher for people with conditions like blocked kidney arteries or severe heart failure. Regular lab tests are recommended to monitor kidney health, and any changes in urination, fatigue, nausea, or chills should be reported to your provider.

• High Potassium Levels: Trandolapril can occasionally increase potassium levels in the body, posing potential health risks. This is more likely if you have diabetes, kidney issues, or are on medications that raise potassium. Alert your provider if you notice symptoms such as nausea, muscle weakness, or an irregular heartbeat.

• Dry Cough: A common side effect of trandolapril is a persistent dry cough due to the blocking of a protein called bradykinin. This cough typically resolves after stopping the medication. Discuss with your doctor if this becomes bothersome.

Contraindications:

• Avoid using trandolapril if you have a history of angioedema.
• Do not take trandolapril in conjunction with aliskiren (Tekturna) if you have diabetes.
• Avoid using trandolapril within 36 hours of taking Entresto (sacubitril/valsartan).

These guidelines are crucial for maintaining your safety while using trandolapril. Always consult with your healthcare provider for personalized advice and management of your condition.

When taking this medication, you may experience some common side effects as your body adjusts. These include dizziness, lightheadedness, tiredness, and a dry cough. Most of these effects are mild and tend to diminish over time. To help manage dizziness and lightheadedness, try rising slowly from sitting or lying positions. It's important to monitor these symptoms and consult your healthcare provider if they persist or worsen.

Some individuals may also experience indigestion, a slow heart rate, and muscle pain. If you find these symptoms concerning, it's advisable to contact your healthcare provider. Occasionally, the medication may cause higher uric acid levels or low blood pressure.

There are also rare but serious side effects that need immediate medical attention. These include angioedema, characterized by severe swelling of the face, arms, legs, lips, tongue, or throat, and dangerously low blood pressure, which may present as pale skin or feeling faint. Serious kidney problems might occur, leading to reduced urine output or swelling in the limbs. High potassium levels can cause nausea, muscle weakness, or an abnormal heartbeat. Furthermore, this medication can rarely lead to severe liver issues, indicated by symptoms such as yellowing of the skin or eyes, dark urine, or persistent nausea and vomiting.

In very rare cases, a serious allergic reaction might occur, presenting as a rash, itching, or trouble breathing. If you encounter any of these symptoms, seek medical help immediately. This summary provides an overview of potential side effects; if you notice any other unusual symptoms, reach out to your healthcare provider for guidance.

Trandolapril may interact with various medications and supplements, making it important to inform your healthcare provider about all medicines and supplements you are taking. This includes prescription drugs, over-the-counter medications, vitamins, and herbal supplements. Some medicines that should not be used with Trandolapril include aliskiren and sacubitril. If these are part of your treatment plan, your doctor may seek alternative options.

There are also medicines that are generally not recommended to be taken with Trandolapril unless absolutely necessary. If used together, your doctor might adjust the dosage or frequency for one or both drugs. These include medications like everolimus, sirolimus, lithium, and various potassium-increasing drugs such as losartan and valsartan.

Additionally, some medications might increase the risk of side effects when used with Trandolapril, but they might still be essential for your treatment. In such cases, your doctor will carefully manage your dosage and monitor your health. This category includes drugs like ibuprofen and naproxen.

Moreover, if you are undergoing desensitization injections for bee or wasp sting allergies, inform your doctor if you are taking Trandolapril, as a significant reaction could occur.

Always keep all your healthcare providers informed about your full medication list to ensure safe and effective treatment.