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Isotretinoin is a medication prescribed for treating severe nodular acne that has not improved with other treatments like topical benzoyl peroxide, clindamycin, or oral antibiotics such as tetracycline and minocycline. This drug, classified as a retinoid, functions by reducing the production of facial oil (sebum), which is a major contributor to severe acne. High levels of sebum can lead to acne, and if not treated, may result in permanent scarring. Isotretinoin is taken orally twice a day, typically over a period of 4 to 5 months. It is particularly important for individuals who can become pregnant to undergo pregnancy tests and use birth control before, during, and after the treatment due to the risk of serious birth defects. Common side effects of isotretinoin include dry lips, dry skin, back pain, and dry eyes. Although previously sold under the brand name Accutane, isotretinoin is now available under other brand names such as Claravis and Amnesteem, as well as in generic forms.