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Isotretinoin

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generic Accutane, Amnesteem, Claravis, Absorica, Zenatane

This medication is used to treat severe cystic acne (also known as nodular acne) that has not responded to other treatment (such as benzoyl peroxide or clindamycin applied to the skin or tetracycline or minocycline taken by mouth). It belongs to a class of drugs known as retinoids. It works by decreasing facial oil (sebum) production. High amounts of sebum can lead to severe acne. If left untreated, severe acne may cause permanent scarring.
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10MG, Isotretinoin (30 Capsules)

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Warnings

Women who are pregnant must not use isotretinoin. Women must avoid becoming pregnant while taking this medication. Serious (sometimes fatal) birth defects, miscarriages, and premature births have occurred when this drug has been used during pregnancy. For female patients, two effective forms of birth control (or complete avoidance of sexual intercourse) must be used for 1 month before starting isotretinoin, during use, and for 1 month after stopping this drug. You must also have monthly pregnancy-avoidance counseling from your doctor. Do not use minipills for birth control (non-estrogen-containing pills) since they may not work as well with isotretinoin. If you are late in having your period, or if you have sexual intercourse at any time without using two effective forms of birth control, stop taking this medication and contact your doctor right away. (See also the Precautions section.) To receive isotretinoin in the United States, you must understand, agree to, and carefully follow the requirements of the REMS Program for this medication. If you live in Canada or any other country, consult your doctor and pharmacist for your country's regulations. Talk with your doctor about the risks and benefits of using this medication.

Isotretinoin Side Effects

Dry lips and mouth, minor swelling of the eyelids or lips, crusty skin, nosebleeds, upset stomach, or thinning of hair may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. To relieve dry mouth, suck on (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as depression, anxiety, thoughts of suicide), tingling feeling in the skin, back/joint/muscle pain, signs of infection (such as sore throat that doesn't go away, fever), painful swallowing, peeling skin on palms/soles. Isotretinoin may rarely cause disease of the pancreas (pancreatitis) that may rarely be fatal. Stop taking this medication and tell your doctor right away if you develop: severe stomach pain, nausea/vomiting that is severe or doesn't stop. Stop taking this medication and tell your doctor right away if you have any very serious side effects, including: severe headache, vision changes, ringing in the ears, hearing loss, chest pain, yellowing eyes/skin, dark urine, severe diarrhea, rectal bleeding. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Interactions

Some products that may interact with this drug are: tetracyclines (such as minocycline, tetracycline), vitamin A-type drugs (such as acitretin, bexarotene), vitamin A, drugs that cause bone loss (for example, anti-seizure drugs such as phenytoin, corticosteroids such as prednisone). Tell your doctor when you start any new drug, and discuss if you should use reliable backup birth control. Also tell your doctor if you have any new spotting or breakthrough bleeding, because these may be signs that your birth control is not working well. ()
Isotretinoin FAQs
Are isotretinoin and Accutane the same?

Yes, isotretinoin and Accutane refer to the same medication. Isotretinoin is the generic name, while Accutane was a brand name for the drug. Accutane is no longer available under that brand name, but isotretinoin is still available under other brand names and as a generic.

Isotretinoin is not banned in the United States. It is a prescription medication used primarily to treat severe acne. However, due to its potential side effects, it is subject to strict regulations and is only available through a special program called iPLEDGE, which ensures that patients, prescribers, and pharmacies comply with safety guidelines.

Isotretinoin primarily works by reducing the size and activity of the sebaceous glands, which decreases the production of sebum. This helps prevent the clogging of pores and reduces the formation of acne. Additionally, isotretinoin has anti-inflammatory properties and can help normalize skin cell turnover, further preventing acne formation. It is typically used for severe acne that has not responded to other treatments.

Yes, isotretinoin is considered a high-risk medication. It is primarily used to treat severe acne and has significant potential side effects. The most notable risk is its teratogenicity, meaning it can cause severe birth defects if taken during pregnancy. Therefore, strict guidelines, such as the iPLEDGE program in the United States, are in place to prevent pregnancy during treatment. Other potential side effects include liver damage, increased cholesterol levels, and mental health effects. Regular monitoring by a healthcare provider is essential during isotretinoin treatment.

The greatest side effect of isotretinoin is its teratogenicity, meaning it can cause severe birth defects if taken during pregnancy. It is crucial for individuals who are pregnant or may become pregnant to avoid using isotretinoin. Additionally, isotretinoin can cause other significant side effects, such as dry skin, lips, and eyes, as well as potential mood changes and liver function alterations. Regular monitoring by a healthcare provider is essential during treatment.

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