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This medication comes with important safety information that outlines potential risks and precautions. Please review these details thoroughly and discuss any concerns with your healthcare provider.

• Serotonin Syndrome: This rare but serious condition can occur when there is an excess of serotonin in the brain. Chlorpheniramine may increase serotonin levels, especially when combined with other serotonin-affecting drugs (such as antidepressants, lithium, MAOIs, or Parkinson’s medications) or if taken in excessive amounts. Symptoms include rapid heartbeat, sweating, muscle stiffness, fever, and confusion. If you experience any of these, seek immediate medical attention. Always inform your healthcare provider about all the medications and supplements you are using to prevent interactions.

• Impaired Driving Ability: Chlorpheniramine/phenylephrine may impair your focus, thinking, and reaction times. Alcohol and other sedatives (like benzodiazepines and opioids) can increase this effect. Avoid driving or operating machinery until you know how the medication affects you.

• Exacerbation of Medical Conditions: This medication can worsen certain health issues. Inform your provider if you have a history of heart disease, high blood pressure, glaucoma, thyroid disorders, diabetes, respiratory problems, or urinary difficulties. This will help determine if chlorpheniramine/phenylephrine is suitable for you.

• Contraindications: Do not use this medication if you are currently taking an MAOI or have taken one in the last 14 days, as this can lead to serious health risks. Always consult your healthcare provider if this applies to you.

These precautions are crucial for ensuring safe use of this medication. Always follow your healthcare provider’s recommendations and report any unusual symptoms or concerns.

When taking this medication, some individuals may experience common side effects such as drowsiness, dizziness, dry mouth, headache, upset stomach, constipation, or trouble sleeping. These are generally mild and often subside on their own. If they persist or worsen, it is advisable to consult a healthcare professional for guidance.

In rare instances, more serious side effects can occur, which require prompt medical attention. These include mental or mood changes like confusion or hallucinations, ringing in the ears, difficulty urinating, or vision changes such as blurred or double vision. Immediate medical help is crucial if you experience a fast or irregular heartbeat or seizures, as these may indicate a severe reaction.

Very rarely, an allergic reaction may happen, characterized by symptoms such as a rash, itching, swelling (particularly of the face, tongue, or throat), severe dizziness, or difficulty breathing. If you notice any of these symptoms, seek emergency medical assistance right away.

It is important to be aware of serotonin syndrome, though uncommon, which includes symptoms like a fast heart rate, sweating, muscle stiffness or spasms, fever, and confusion. Heart palpitations and increased blood pressure are also serious concerns that warrant immediate medical care. Always monitor your health and report any unusual symptoms to your healthcare provider.

Certain products and medications can interact with this drug. Avoid using skin-applied antihistamines like diphenhydramine creams or sprays. Taking this medication with MAO inhibitors is dangerous and can result in severe, potentially fatal reactions. MAO inhibitors such as isocarboxazid, linezolid, and others listed should not be used while on this medication, and most should also be avoided for two weeks before starting treatment. Consult your doctor for guidance on when to begin or discontinue use.

If you are taking other medications that cause drowsiness, inform your doctor or pharmacist. These include opioid pain or cough medications like codeine and hydrocodone, alcohol, marijuana, sleep or anxiety medications like alprazolam, lorazepam, and zolpidem, muscle relaxants such as carisoprodol and cyclobenzaprine, as well as other antihistamines like cetirizine and diphenhydramine.

Check the labels on your medications, including those for allergies or cold and cough, as they might contain ingredients that cause drowsiness. Consult your pharmacist on their safe use. This medication may also affect certain medical or laboratory tests, such as brain scans for Parkinson's disease, urine drug screenings, and allergy skin tests, potentially leading to inaccurate results. Ensure all healthcare providers and lab personnel are aware of your medication use.