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This medication comes with important safety warnings and contraindications that should be carefully considered. Please review the following information and discuss any concerns with your healthcare provider to ensure safe use.

• Infection Risks from Sharing Supplies: Do not share Novolin N pens, syringes, needles, or cartridges with others to prevent the transmission of serious infections.

• Blood Sugar Level Variability: Alterations in your insulin regimen, such as changing the injection site, insulin type, or brand, can impact your body's response, potentially causing high or low blood sugar levels. Avoid injecting into areas with skin issues like pitting or thickening (lipodystrophy), as this may lead to elevated blood sugar.

• Hypoglycemia Risk: Novolin N may cause dangerously low blood sugar (hypoglycemia), which can be life-threatening if not promptly addressed. Regularly monitor your blood sugar levels, especially if there are changes in diet, exercise, alcohol consumption, or if you're using other diabetes medications. Liver or kidney issues may also increase this risk.

• Low Potassium Levels: This medication may decrease potassium levels, potentially leading to serious complications. Be vigilant if you experience symptoms such as muscle weakness, cramps, nausea, vomiting, or irregular heartbeat, and inform your prescriber if you're taking diuretics or other potassium-lowering drugs.

• Fluid Retention and Heart Failure Risk: Using Novolin N with glitazones (e.g., pioglitazone) can cause fluid retention, which may exacerbate or lead to heart failure. Report any signs like sudden weight gain, swelling, breathing difficulties, or fatigue to your healthcare provider, as adjustments to your treatment may be necessary.

Contraindications:

• Do not use this medication during episodes of low blood sugar (hypoglycemia), as it can pose serious health risks.

Always consult with your healthcare provider if you have any pre-existing conditions or are taking other medications that may interact with Novolin N.

When using this medication, some individuals may experience common side effects, which are generally mild and manageable. These include reactions at the injection site, such as pain, redness, or irritation, as well as weight gain. If these symptoms persist or worsen, it's advisable to consult with your healthcare provider.

The medication can also cause low blood sugar (hypoglycemia), especially if you skip meals or engage in strenuous exercise. Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling in the hands and feet. To manage low blood sugar, keep glucose tablets or gel handy, or consume a quick source of sugar like candy or fruit juice. On the other hand, high blood sugar (hyperglycemia) might manifest as increased thirst and urination; inform your healthcare provider immediately if these occur.

Serious side effects, though rare, demand urgent medical attention. These include severe hypoglycemia, which may present as confusion, irritability, extreme hunger, and difficulty thinking clearly. Ketoacidosis, characterized by symptoms like nausea, vomiting, fatigue, and fruity breath, and dangerously low potassium levels, which might cause muscle cramps, constipation, or an irregular heartbeat, are also severe concerns. Additionally, a severe allergic reaction, indicated by rash, hives, or swelling of the face, tongue, and throat, requires immediate medical help.

If you encounter any side effects not listed here, it's important to contact your healthcare provider for advice.