Orkambi Coupons & Discount Card – Guaranteed Prices from $6190.84
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100-125MG, Orkambi (30 Tablets)
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Rite Aid
$6190.84
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$6190.84
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Related CFTR potentiators prescriptions
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Related CFTR potentiators prescriptions
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Orkambi dosage forms
| Dosage | Quantity | Price from | Per unit |
|---|---|---|---|
| 200-125MG | 30 Tablets | $6276.28 | $209.21 |
| 100-125MG | 30 Tablets | $6276.28 | $209.21 |
Orkambi Warnings
The following outlines the crucial safety information regarding the use of Orkambi (lumacaftor / ivacaftor). It is essential to review these details and discuss any concerns with your healthcare professional.
Liver Health Monitoring: Orkambi may lead to elevated liver enzyme levels. Prior to initiating treatment, and periodically thereafter, liver function tests will be conducted. Those with existing liver conditions will require more frequent monitoring.
Breathing Difficulties: Some patients have reported chest discomfort and shortness of breath. These symptoms can be severe enough to discontinue use. It is vital to report any respiratory issues to your healthcare provider, especially if you have advanced lung disease (FEV1 less than 40).
Blood Pressure Increase: Orkambi can elevate blood pressure. Regular monitoring of blood pressure is advised while on this medication.
Drug Interactions: Concurrent use of Orkambi with other medications may alter drug levels, efficacy, and side effect risks. Discuss all medications with your healthcare provider to manage potential interactions effectively.
Risk of Cataracts in Children: There is a potential risk for developing cataracts, particularly in children. Regular eye examinations are recommended for children undergoing treatment with Orkambi, especially if they are also exposed to steroid medications or radiation.
In case of any concerns or unusual symptoms, please consult your healthcare provider promptly.
Orkambi Side Effects
When taking this medication, some individuals may experience common side effects, which are generally mild. These can include nausea, diarrhea, tiredness, rash, and gas. It is also possible to develop flu-like symptoms or upper respiratory tract infections, such as a cold or sore throat. If these symptoms persist or become bothersome, consulting a healthcare provider is advisable.
In addition to the common side effects, some users may notice irregular menstrual cycles or increased menstrual bleeding, as well as a rise in blood pressure. Due to this potential, it's recommended to monitor your blood pressure regularly.
There are rare, yet serious side effects that warrant immediate medical attention. Signs of liver damage, such as persistent nausea or vomiting, a loss of appetite, stomach pain, yellowing of the skin or eyes, and dark-colored urine, should be addressed promptly. Individuals with severe lung disease should be cautious, as starting this medication might lead to breathing difficulties, such as chest pain or shortness of breath.
Although a rash can commonly occur, it is usually not severe. However, any rash should be reported to a healthcare provider to rule out the possibility of a severe allergic reaction, which, although rare, can include symptoms like severe dizziness or trouble breathing. If you notice these or any other unlisted effects, seeking medical advice is crucial.
Orkambi Interactions
What is the drug ORKAMBI used for?
ORKAMBI is used for the treatment of cystic fibrosis in patients who are 2 years of age and older and have two copies of the F508del mutation in the CFTR gene. It works by improving the function of the defective protein made by the CFTR gene, thereby helping to manage the symptoms of cystic fibrosis.
How much does ORKAMBI cost?
The cost of ORKAMBI can vary significantly based on factors such as insurance coverage, pharmacy, and location. Without insurance, the list price can be quite high, often exceeding several hundred thousand dollars annually. Patients are encouraged to check with their insurance provider for specific coverage details and potential out-of-pocket costs. Additionally, Vertex Pharmaceuticals, the manufacturer, offers a patient assistance program that may help reduce costs for eligible individuals.
Is ORKAMBI approved by the FDA?
Yes, ORKAMBI is approved by the FDA. It was first approved in July 2015 for the treatment of cystic fibrosis in patients aged 12 years and older with specific genetic mutations.
Why is Trikafta better than ORKAMBI?
Trikafta is considered more effective than Orkambi for many patients with cystic fibrosis because it targets a broader range of CFTR mutations, including the most common F508del mutation. Trikafta combines three medications (elexacaftor, tezacaftor, and ivacaftor) that work together to improve the function of the CFTR protein more effectively than the two-drug combination in Orkambi (lumacaftor and ivacaftor). This results in better lung function, fewer pulmonary exacerbations, and improved quality of life for many patients.
How much is ORKAMBI without insurance?
The cost of ORKAMBI without insurance can vary, but it is generally quite expensive. As of the latest information, the price can be around $20,000 to $30,000 for a 28-day supply. Prices may vary based on the pharmacy and location. It is advisable to check with local pharmacies for the most accurate pricing.