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The following outlines crucial safety information regarding the use of pancrelipase (Creon). Please read carefully and consult your healthcare provider with any concerns or questions.

• Colon Scarring (Fibrosing Colonopathy): Using pancrelipase (Creon) in high doses or over extended periods can cause serious colon scarring, particularly in children with cystic fibrosis. Always follow your healthcare provider's dosage recommendations and avoid exceeding the prescribed duration.

• Mouth Irritation: To prevent mouth irritation, swallow pancrelipase (Creon) capsules whole without chewing or crushing them. If preferred, you can sprinkle the capsule contents on apple sauce, but ensure immediate swallowing followed by a drink of water or juice to prevent residue in the mouth.

• Elevated Uric Acid Levels: Pancrelipase (Creon) may increase uric acid levels, potentially leading to gout. If you have pre-existing conditions like gout, kidney issues, or high uric acid levels, discuss these with your healthcare provider.

• Infection Risk: Although rare, there is a slight possibility of viral infection due to the pig-derived nature of pancrelipase (Creon). The manufacturing process is designed to eliminate viruses, making this risk minimal. Consult your healthcare provider if this is a concern.

• Allergic Reactions: If you are allergic to pork products, discuss with your healthcare provider whether pancrelipase (Creon) is suitable for you. Seek immediate medical attention if you experience difficulty breathing, rashes, or facial/throat swelling, as these may indicate an allergic reaction.

Please note this medication has no listed contraindications. Always adhere to your healthcare provider's instructions for safe and effective use of pancrelipase (Creon).

When taking this medication, you might experience some common side effects such as diarrhea, constipation, headache, stomach pain or cramps, bloating, gas, cough, nausea, vomiting, dizziness, or changes in your stool or bowel movements. These effects are usually mild and should not cause concern, but if they persist or worsen, it is advisable to consult your healthcare provider. Additionally, some individuals might notice changes in blood sugar levels, which can fluctuate up or down.

On rare occasions, more severe side effects can occur. These include severe constipation, intense abdominal discomfort, frequent or painful urination, and joint pain. It is important to seek medical advice if you encounter any of these serious effects.

Although extremely rare, a severe allergic reaction is possible and requires immediate medical attention. Symptoms of such a reaction might include a rash, itching or swelling, particularly of the face, tongue, or throat, severe dizziness, and trouble breathing. If you experience any of these symptoms, it is crucial to get medical help right away. Always remain attentive to your body's reactions and report anything unusual to your healthcare provider.