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The following safety information outlines crucial warnings associated with the use of Orphengesic Forte. Please review these details carefully and discuss any concerns with your healthcare provider.

• Gastrointestinal Risks: Orphengesic Forte may cause irritation in the stomach or intestines, which could present as stomach pain or heartburn. It could also lead to serious conditions such as swelling, bleeding, or ulcers in these areas. The likelihood of bleeding increases if you are also taking blood thinners like warfarin (Coumadin) or oral corticosteroids. If you experience persistent stomach pain, vomit blood or substances resembling coffee grounds, or notice bloody or black, tarry stools, contact your healthcare provider immediately, as these could indicate bleeding or an ulcer. The risk is elevated for individuals with a history of stomach bleeding or ulcers, bleeding disorders, concurrent use of other NSAIDs, blood thinners, or oral corticosteroids, alcohol use, those aged 60 or older, long-term users of Orphengesic Forte, or those taking higher than recommended doses.

• Pregnancy Risks: For individuals who are 20 weeks pregnant or more, Orphengesic Forte may harm the unborn baby by affecting kidney function and amniotic fluid levels. After 30 weeks of pregnancy, it can cause heart defects in the unborn child. It is advisable to consult your healthcare provider for safer medication alternatives during pregnancy.

• Severe Allergic or Skin Reactions: Although rare, Orphengesic Forte can trigger serious allergic or skin reactions. Symptoms may include fever, facial swelling, skin reddening or peeling, painful rash, or fluid-filled blisters. If any of these occur, discontinue use and seek emergency medical assistance promptly.

Contraindications:

Orphengesic Forte should not be used if you have any of the following conditions, as it could pose significant health risks. Consult your healthcare provider before use if you have:

• Glaucoma
• Blockages in the stomach, intestines, or other parts of the digestive tract
• Enlarged prostate or bladder problems
• Myasthenia gravis, a nerve condition affecting muscles and movement
• A severe allergic reaction to aspirin or other NSAIDs
• Sensitivity to caffeine

It is vital to adhere to these guidelines to prevent potential health risks and complications.

When taking this medication, some individuals may experience mild side effects such as dry mouth, dizziness, drowsiness, lightheadedness, blurred vision, upset stomach, heartburn, nausea, vomiting, constipation, or trouble sleeping. These symptoms are generally not severe and often resolve on their own. If they persist or worsen, it is advisable to consult your healthcare provider for guidance. To alleviate dry mouth, consider using sugarless gum, candy, or saliva substitutes and drink plenty of water.

There are also more serious side effects that require prompt medical attention. These include mental or mood changes like confusion, anxiety, or hallucinations, as well as physical symptoms such as shaking, fast or irregular heartbeat, difficulty urinating, easy bruising, fainting, eye pain, and unusual tiredness. Moreover, signs of kidney problems, such as changes in urine output, yellowing of the eyes or skin, and dark urine, should not be ignored.

Rare but severe side effects include significant stomach bleeding, indicated by persistent abdominal pain, black stools, or vomit resembling coffee grounds. Serious allergic reactions, characterized by symptoms like fever, swollen lymph nodes, rash, severe dizziness, or trouble breathing, also require immediate medical intervention. In extremely rare cases, symptoms like extreme tiredness, confusion, or skin reactions such as reddening, peeling, or blistering may occur, indicating the need for urgent care. Always reach out to your healthcare provider if you experience any concerning symptoms.

Certain medications may interact with this drug, affecting how it works or increasing your risk of side effects. Medicines such as dichlorphenamide, Methotrexate, Mifepristone, and vemurafenib are known to interact. Additionally, this medication can elevate the risk of bleeding if taken with other drugs that also pose a bleeding risk, like anti-platelet medications (e.g., Clopidogrel) and anticoagulants or "blood thinners" (e.g., Dabigatran, Enoxaparin, Warfarin).

Be cautious with over-the-counter pain relievers or fever reducers, such as Aspirin and NSAIDs (e.g., Ibuprofen, Ketorolac, Naproxen), as they may increase the likelihood of side effects when used with this medication. Consult your doctor or pharmacist for guidance.

It is also important to inform your healthcare provider if you're using other substances that cause drowsiness. These include opioid pain relievers (e.g., codeine, Hydrocodone), alcohol, marijuana, medications for sleep or anxiety (e.g., Alprazolam, Lorazepam, Zolpidem), muscle relaxants (e.g., Carisoprodol, Cyclobenzaprine), or antihistamines (e.g., Cetirizine, diphenhydramine). Check your medication labels—especially those for allergy or cold products—as they might also contain ingredients that induce drowsiness. Speak with your pharmacist for safe usage advice.

Lastly, this medication may affect the results of certain medical or lab tests, such as dipyridamole-thallium imaging and specific urine tests, potentially leading to inaccurate results. Ensure that all medical personnel and your healthcare providers are aware that you are taking this medication.