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The following safety information outlines important considerations and potential risks associated with the use of this medication. Please review these details carefully and consult your healthcare provider if you have any questions or concerns.

• Brain, Heart, and Lung Complications: Lidocaine (Xylocaine) can cause serious issues such as slowed or stopped breathing, low blood pressure, and decreased heart rate. It can also weaken your heart's ability to pump effectively. Your healthcare provider will monitor your heart and respiration closely while using lidocaine for local anesthesia to prevent adverse reactions. Notify your provider immediately if you experience symptoms such as restlessness, drowsiness, anxiety, dizziness, ringing in the ears, blurred vision, or tremors. These could indicate early signs of lidocaine-induced brain issues. Risks include high doses of lidocaine, a history of heart or lung problems, and use in the head and neck area.

• Serious Allergic Reactions: Although rare, lidocaine (Xylocaine) can cause life-threatening allergic reactions. The risk is higher if you have had previous allergies to lidocaine, similar local anesthetics, or methylparaben, a preservative. Inform your healthcare provider of any known medical allergies prior to receiving an injection. Your provider may select an alternative anesthetic that is safer for you. Be vigilant for symptoms of an allergic reaction, such as itching, swelling, wheezing, difficulty breathing, or rash, and seek immediate medical attention if they occur. Risks include allergies to lidocaine, similar medications, or methylparaben.

• Methemoglobinemia (Blood Disorder): Lidocaine can lead to methemoglobinemia, a serious condition where red blood cells fail to transport enough oxygen throughout the body. Your risk increases if you have a deficiency in G6PD, a hereditary condition affecting red blood cells, or if you have been exposed to oxidizing chemicals like chlorine and hydrogen peroxide, commonly found in cleaning supplies and hair dye. Symptoms can manifest immediately or within hours of lidocaine use and include headache, fatigue, and bluish skin. Report these symptoms to your provider promptly to prevent severe complications such as seizures, loss of consciousness, or abnormal heart rhythms. Risks include a history of methemoglobinemia, low G6PD levels, heart or lung issues, age under 6 months, and exposure to oxidizing agents.

• Contraindications: This medication should not be used if you have an allergy to amide-type local anesthetics, as it may pose severe health risks. Always consult with your healthcare provider if this applies to you.

Please ensure all necessary precautions are taken and discuss any concerns with your healthcare provider to ensure safe use of this medication.

When taking this medication, some individuals might experience common side effects such as headaches, back pain, and shivering, which occur in approximately 3%, 3%, and 2% of users respectively. These are generally mild, but it's advisable to consult a healthcare provider if they persist or worsen.

In addition to these, other side effects reported include nervousness, anxiety, ringing in the ears, blurry vision, nausea, vomiting, and double vision. Although these are less common, they should not be ignored, especially if they become severe.

There are also rare but serious side effects that demand immediate medical attention. These include blood problems like methemoglobinemia, which can present as seizures, loss of consciousness, fast heartbeat, trouble breathing, dizziness, fatigue, and a bluish discoloration of the skin. An excessive amount of lidocaine in the body can cause drowsiness, confusion, slow heartbeat, breathing difficulties, and lack of muscle control. Serious allergic reactions may manifest as facial swelling, breathing difficulties, trouble speaking, throat constriction, red and itchy rash, lightheadedness, or clammy skin. If any of these serious symptoms occur, seek urgent medical care.