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The following safety information outlines important considerations and potential risks associated with the use of this medication. Please review these details carefully and consult your healthcare provider if you have any questions or concerns.

• Brain, Heart, and Lung Complications: Lidocaine (Xylocaine) can cause serious issues such as slowed or stopped breathing, low blood pressure, and decreased heart rate. It can also weaken your heart's ability to pump effectively. Your healthcare provider will monitor your heart and respiration closely while using lidocaine for local anesthesia to prevent adverse reactions. Notify your provider immediately if you experience symptoms such as restlessness, drowsiness, anxiety, dizziness, ringing in the ears, blurred vision, or tremors. These could indicate early signs of lidocaine-induced brain issues. Risks include high doses of lidocaine, a history of heart or lung problems, and use in the head and neck area.

• Serious Allergic Reactions: Although rare, lidocaine (Xylocaine) can cause life-threatening allergic reactions. The risk is higher if you have had previous allergies to lidocaine, similar local anesthetics, or methylparaben, a preservative. Inform your healthcare provider of any known medical allergies prior to receiving an injection. Your provider may select an alternative anesthetic that is safer for you. Be vigilant for symptoms of an allergic reaction, such as itching, swelling, wheezing, difficulty breathing, or rash, and seek immediate medical attention if they occur. Risks include allergies to lidocaine, similar medications, or methylparaben.

• Methemoglobinemia (Blood Disorder): Lidocaine can lead to methemoglobinemia, a serious condition where red blood cells fail to transport enough oxygen throughout the body. Your risk increases if you have a deficiency in G6PD, a hereditary condition affecting red blood cells, or if you have been exposed to oxidizing chemicals like chlorine and hydrogen peroxide, commonly found in cleaning supplies and hair dye. Symptoms can manifest immediately or within hours of lidocaine use and include headache, fatigue, and bluish skin. Report these symptoms to your provider promptly to prevent severe complications such as seizures, loss of consciousness, or abnormal heart rhythms. Risks include a history of methemoglobinemia, low G6PD levels, heart or lung issues, age under 6 months, and exposure to oxidizing agents.

• Contraindications: This medication should not be used if you have an allergy to amide-type local anesthetics, as it may pose severe health risks. Always consult with your healthcare provider if this applies to you.

Please ensure all necessary precautions are taken and discuss any concerns with your healthcare provider to ensure safe use of this medication.

When using Xylocaine (Lidocaine), it's important to be aware of potential interactions with other medications, as these can affect its safety and effectiveness. Here are some key considerations:

Medications That May Interact with Xylocaine:

• Other Local Anesthetics and Related Drugs: Combining Xylocaine with other local anesthetics or medications structurally similar to amide-type local anesthetics, such as certain anti-arrhythmic drugs like Mexiletine, can increase the risk of additive toxic effects.

• Medications Affecting Lidocaine Clearance: Drugs that reduce the body's ability to clear lidocaine, such as Cimetidine (used for ulcers and reflux) and beta-blockers (used for high blood pressure), may lead to higher levels of lidocaine in the blood, increasing the risk of toxicity.

• Monoamine Oxidase Inhibitors (MAOIs) and Tricyclic Antidepressants: If Xylocaine solutions containing epinephrine are used in patients taking MAOIs or tricyclic antidepressants, there is a risk of severe and prolonged high blood pressure.

• Phenothiazines and Butyrophenones: These medications can reduce or reverse the blood pressure-raising effects of epinephrine, potentially leading to low blood pressure and rapid heart rate.

• Vasopressor Drugs and Ergot-Type Oxytocic Drugs: Using Xylocaine with these drugs may cause severe, persistent high blood pressure or cerebrovascular accidents.

Increased Risk of Methemoglobinemia:

Methemoglobinemia is a condition where the blood's ability to carry oxygen is reduced. The risk of developing this condition increases when Xylocaine is used alongside certain medications, including:

• Nitrates/Nitrites: Such as nitric oxide and Nitroglycerin.

• Other Local Anesthetics: Including Benzocaine and prilocaine.

• Antineoplastic Agents: Like Cyclophosphamide and Flutamide.

• Antibiotics: Such as Dapsone and sulfonamides.

• Antimalarials: Including chloroquine and Primaquine.

• Anticonvulsants: Like Phenobarbital and Phenytoin.

• Other Drugs: Such as Acetaminophen and Metoclopramide.

Alcohol and Food Interactions:

• Alcohol: Consuming alcohol while using Xylocaine may lead to side effects like sweating, low blood pressure, rapid heartbeat, irregular heartbeats, nausea, vomiting, dizziness, and fainting.

• Food: If Xylocaine is applied to the mouth or throat, avoid eating or drinking for at least one hour to prevent accidental injury due to numbness.

Disease Interactions:

Before using Xylocaine, inform your healthcare provider if you have conditions such as liver or kidney issues, epilepsy, heart problems, infections or open wounds at the application site, malignant hyperthermia, or a family history of malignant hyperthermia. These conditions may affect the safety and effectiveness of Xylocaine.

Always consult with your healthcare provider before starting or stopping any medication, including over-the-counter drugs and supplements, to ensure safe use of Xylocaine.