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The following safety information provides crucial guidance regarding the use of oxymetazoline (Afrin). It is essential to understand these warnings to ensure safe and effective use of the medication. If you have any questions or concerns, please consult your healthcare provider.

• Rebound Congestion: Avoid using oxymetazoline (Afrin) for more than three consecutive days. Prolonged use can result in rebound congestion, where symptoms worsen or return after discontinuation. Consult with your primary care provider or pharmacist for alternative long-term solutions for congestion relief.

• Medical Condition Precautions: Individuals with specific medical conditions such as high blood pressure, heart disease, or diabetes should exercise caution when using oxymetazoline (Afrin). Although it may not significantly raise blood pressure compared to other decongestants, it poses a risk for those with pre-existing conditions. Always seek advice from your healthcare provider before starting this medication if you have these conditions.

• Intended Use: Oxymetazoline (Afrin) is designed exclusively for nasal use. Do not administer the medication in any other way. If a nasal spray is not suitable for you, discuss alternative treatments with your pharmacist or primary care provider. In the event of accidental ingestion, especially in young children, serious side effects such as breathing difficulties and slow heart rate may occur. Immediate medical assistance should be sought, or contact a poison control center at 1-800-222-1222.

Remember, this information is intended to ensure your safety while using oxymetazoline (Afrin). Always follow the guidance of your healthcare provider for the best outcomes.

Common side effects:

• Temporary burning or stinging sensations in the nose
• Dryness
• Sneezing
• Runny nose

Less common but important to monitor:

• Rebound nasal congestion

Serious side effects:

• Slow, fast, or pounding heartbeat
• Dizziness
• Nausea
• Headaches
• Mood changes
• Difficulty sleeping
• Tremors
• Unusual sweating
• Weakness
• Serious allergic reaction (rash, itching, swelling particularly of the face, tongue, or throat, severe dizziness, trouble breathing)

It is important to avoid using MAO inhibitors with this medication, as this combination may lead to a severe and potentially life-threatening interaction. MAO inhibitors such as isocarboxazid, linezolid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, and Tranylcypromine should not be taken while on this medication. Additionally, most MAO inhibitors must be discontinued at least two weeks before starting this treatment. Consult with your doctor about the appropriate timing for starting or stopping this medication.

Oxymetazoline (Afrin) can also interact with other medications or supplements. It's crucial to inform your doctor and pharmacist about all the medications, including over-the-counter drugs, vitamins, and supplements you are currently taking. Some medicines, such as amineptine, Amitriptyline, Amoxapine, Carvedilol, and many others, may require dosage adjustments or special monitoring if used with Oxymetazoline. Your healthcare provider will guide you on whether these combinations are necessary and how to manage them safely.