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When taking this medication, you might experience dizziness, abdominal pain, dry mouth, nausea, stomach upset, trouble sleeping, and headache. These are common and usually mild. If they persist or worsen, consult your healthcare provider. To prevent dizziness and lightheadedness, rise slowly from sitting or lying positions.

If you are taking levodopa, be aware that it may increase side effects such as nausea, shakiness, muscle stiffness, and mental changes like hallucinations or abnormal dreams. Discuss any concerns with your healthcare provider, who may adjust your medication or dosage.

A rare but serious side effect is suddenly falling asleep during daily activities, sometimes without prior drowsiness. Avoid driving or engaging in potentially hazardous tasks if this occurs, and discuss it with your healthcare provider. Alcohol and other sedatives may increase this risk.

Serious side effects requiring immediate medical attention include fainting, balance loss, mental changes (agitation, confusion, depression, hallucinations), unusual urges (gambling, sexual), worsening muscle stiffness/twitching, changes in sexual function, increased shaking, swollen ankles/legs, difficulty urinating, unusual weight changes, easy bruising, black/tarry stools, and vomit resembling coffee grounds.

Rarely, this medication may trigger a hypertensive crisis, which can be life-threatening. Symptoms include severe headache, irregular heartbeat, chest pain, neck stiffness, severe nausea/vomiting, clammy skin, widened pupils, vision changes, and sensitivity to light. Immediate medical help is crucial.

The drug may also rarely cause serotonin syndrome, a serious condition, especially if combined with other serotonin-raising medications. Symptoms include hallucinations, restlessness, coordination loss, fast heartbeat, severe dizziness, fever, severe nausea/vomiting/diarrhea, and muscle twitching. Seek medical assistance promptly.

Serious allergic reactions are rare but require immediate attention and include rash, itching/swelling (especially face/tongue/throat), dizziness, and breathing difficulties. This summary does not cover all possible side effects. If you experience any unusual symptoms, contact your healthcare provider.

Selegiline may interact with certain medications, including antidepressants like bupropion, maprotiline, and mirtazapine, and other MAO inhibitors such as isocarboxazid, linezolid, and rasagiline. It can also interact with appetite suppressants like diethylpropion, ADHD medications such as atomoxetine, and methylphenidate, as well as drugs like apraclonidine, buspirone, and carbamazepine/oxcarbazepine. Cyclobenzaprine, deutetrabenazine, specific herbal products like ephedra, cold medications with phenylephrine or pseudoephedrine, fentanyl, metoclopramide, and certain street drugs like LSD are also included. Other interactions may occur with stimulants, supplements like tryptophan, tetrabenazine, migraine medications such as rizatriptan, and valbenazine.

Taking multiple medications that boost serotonin levels can increase the risk of serotonin syndrome, a potentially dangerous condition. This includes MDMA, St. John's wort, and some antidepressants, such as SSRIs (fluoxetine, paroxetine), SNRIs (duloxetine, venlafaxine), TCAs (amitriptyline, doxepin), and opioids like meperidine and tramadol. The risk is higher when you start or increase these medications.

Inform your healthcare provider if you are using any of these medications before, during, or within two weeks of taking selegiline. If you have used fluoxetine, ensure there is a gap of at least five weeks before starting selegiline. Discuss with your doctor the appropriate timing for starting or stopping these medications with selegiline.

Check all medicine labels, including those for allergies or colds, as they might contain dextromethorphan, decongestants, or stimulants. Consult your pharmacist about their safe use.

To prevent dangerous high blood pressure reactions, follow a diet low in tyramine, as advised by your doctor or dietician. Avoid high-tyramine foods like aged cheeses, fermented meats, and certain alcoholic beverages. Limit moderate-tyramine foods such as avocados, bananas, and chocolate. Get medical help immediately if you experience symptoms of high blood pressure, such as a fast or slow heartbeat, vomiting, sweating, headache, chest pain, vision changes, weakness, or speech difficulties.

Selegiline might interfere with some medical or lab tests, potentially leading to incorrect results. Inform all your healthcare providers and lab staff that you are taking this medication.