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When taking rasagiline, you might experience dizziness, drowsiness, joint pain, heartburn, nausea, dry mouth, weight loss, or stomach pain. These are generally mild and can be managed by standing up slowly from sitting or lying positions to reduce dizziness. Most people using this medication do not encounter severe side effects. However, be vigilant for any serious reactions such as fainting, loss of balance, mental changes like confusion or depression, worsening muscle stiffness or twitching, swelling of the ankles or legs, easy bruising, or unusual strong urges.

There have been cases where individuals suddenly fell asleep during activities without prior drowsiness. If this happens, avoid driving or engaging in dangerous tasks and consult your healthcare provider. Alcohol or other sedative medications may heighten this risk. Rasagiline may also increase serotonin levels, potentially leading to a rare but serious condition called serotonin syndrome. Seek urgent medical attention if you notice symptoms like rapid heartbeat, hallucinations, loss of coordination, severe nausea, or unexplained fever.

Additionally, this drug may rarely trigger a hypertensive crisis, a potentially fatal condition marked by severe headache, irregular heartbeat, chest pain, or vision changes. Seek immediate medical help if these occur. Though rare, serious allergic reactions may also happen, identifiable by rash, itching, swelling, severe dizziness, or breathing difficulties. If you encounter any side effects not mentioned here, contact your healthcare provider promptly for advice.

This medication may interact with several products, including weight loss or appetite suppressants like Diethylpropion, medications for ADHD such as Atomoxetine and Methylphenidate, and other drugs like Apraclonidine, bupropion, Buspirone, Carbamazepine, Cyclobenzaprine, deutetrabenazine, dextromethorphan, Methyldopa, Metoclopramide, and certain supplements like Tryptophan and tyramine. It also includes Tetrabenazine, migraine medications known as "triptans" (e.g., Rizatriptan, Sumatriptan, Zolmitriptan), and valbenazine.

The chance of developing serotonin syndrome or toxicity is heightened if you are also taking drugs that raise serotonin levels. These include substances like MDMA (ecstasy), the herbal supplement St. John's wort, Tramadol, specific opioids (such as Fentanyl, Meperidine, methadone, tapentadol), and various antidepressants. These antidepressants include Maprotiline, Mirtazapine, SSRIs like Fluoxetine and paroxetine, SNRIs like Duloxetine and Venlafaxine, and tricyclics such as Amitriptyline and Doxepin. The risk is especially increased when starting or increasing the dosage of these drugs.

Certain products can interact with rasagiline, whether taken simultaneously or weeks apart. Inform your doctor or pharmacist if you have used any interacting products, or any serotonin-raising drugs, within two weeks before or after taking rasagiline. Additionally, let them know if you have used fluoxetine in the five weeks before starting rasagiline. Your doctor will guide you on how long to wait between starting or stopping these drugs and using rasagiline.

Taking other MAO inhibitors with this medication can lead to severe, potentially fatal interactions. Avoid using any MAO inhibitors, including isocarboxazid, Linezolid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, safinamide, Selegiline, and Tranylcypromine, during rasagiline treatment. Most MAO inhibitors should not be taken for two weeks before and after using this medication. Consult your doctor for specific timing.

Before starting rasagiline, disclose any use of drugs that could cause dangerously high blood pressure when combined with it. This includes herbal products like ephedra (ma huang), certain allergy and cough-and-cold products (including dextromethorphan, decongestants like phenylephrine and pseudoephedrine), and stimulants such as amphetamines, ephedrine, Epinephrine, and Phenylalanine. Rasagiline should not be used with these medications. Discuss further details with your healthcare provider.

Inform your doctor or pharmacist if you are using other products that cause drowsiness, such as alcohol, marijuana (cannabis), antihistamines like Cetirizine and diphenhydramine, sleep or anxiety medications like Alprazolam, Diazepam, and Zolpidem, muscle relaxants like Carisoprodol, and opioid pain relievers such as codeine and hydrocodone.