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This document provides important safety information regarding the use of Formoterol (Perforomist). Please read the following warnings carefully and discuss any concerns with your healthcare provider.

• Risk of Asthma-related Death: Formoterol (Perforomist) is not approved for asthma treatment. There is an increased risk of hospitalization and death related to asthma in some patients using this medication. It should not be used as a rescue inhaler or for asthma management. Patients with a history of asthma should avoid using this medication.

• Exacerbation of COPD Symptoms: Formoterol (Perforomist) is not intended for the management of sudden COPD symptom flare-ups. If a rescue inhaler like albuterol does not alleviate breathing difficulties, seek emergency medical assistance immediately. Consult your healthcare provider if COPD symptoms worsen over time to explore alternative treatment options.

• Sudden Breathing Issues: In rare cases, users may experience immediate breathing difficulties after using Formoterol (Perforomist). If this occurs, use a rescue inhaler promptly and discontinue the use of Formoterol (Perforomist). Discuss alternative medications with your healthcare provider.

• Cardiovascular Concerns: Formoterol (Perforomist) may increase blood pressure and heart rate. Discontinue use if you experience these symptoms and consult your healthcare provider. This risk is heightened in individuals with a history of heart disease, abnormal heart rhythms, high blood pressure, or those exceeding the prescribed dosage.

Please adhere to the recommended usage guidelines for Formoterol (Perforomist) and consult your healthcare provider for any questions or concerns regarding your health condition or medication regimen.

When taking this medication, you may experience some common side effects such as shakiness, nausea, headache, nervousness, dizziness, dry mouth, or trouble sleeping. These effects are usually mild and often improve with time. However, if they persist or worsen, it is important to consult your healthcare provider. Additionally, be aware that this medication can potentially increase blood pressure, so regular monitoring is advised.

In some cases, more serious side effects can occur, including muscle weakness, cramps, increased thirst, and increased urination. If you experience any of these, seek medical advice promptly. Rarely, there can be severe side effects like chest pain, severe dizziness, fainting, or a fast or irregular heartbeat, which require immediate medical attention. Of particular concern is the rare occurrence of paradoxical bronchospasm, a sudden worsening of breathing problems. If you encounter breathing difficulties or sudden wheezing, use your quick-relief inhaler and get medical help right away.

Although a very serious allergic reaction to this medication is uncommon, it is important to be vigilant. Seek immediate medical assistance if you notice symptoms such as rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing. Always discuss any unexpected effects with your healthcare provider, as this is not a complete list of possible side effects.

When using Formoterol (Perforomist), it is crucial to avoid simultaneously using other long-acting beta agonists (LABA) such as arformoterol and salmeterol, as this could lead to excessive stimulation of beta receptors, increasing the risk of adverse effects like palpitations or elevated heart rate.

Additionally, Formoterol may have interactions with various medications and supplements. Inform your healthcare provider and pharmacist about all the prescriptions, over-the-counter medications, vitamins, and herbal products you are currently taking. Although not exhaustive, the following list highlights significant interactions:

Formoterol should not be combined with certain medications, as these combinations can increase the risk of severe side effects. Medications such as Bepridil, Cisapride, Dronedarone, Mesoridazine, Pimozide, Piperaquine, Saquinavir, Sparfloxacin, Terfenadine, Thioridazine, and Ziprasidone fall into this category. Your doctor might choose alternative treatments or adjust your current medications if you're using any of these.

In some situations, you may need to use Formoterol alongside medications like Acebutolol, Amiodarone, and many others listed, but this is generally not recommended unless necessary. If both are prescribed, your doctor might modify the dosage or frequency of one or both drugs to mitigate potential interactions.

Always follow your healthcare provider’s instructions and discuss any concerns about drug interactions with them.