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The safety information and warnings below detail important considerations for the use of Symbicort (budesonide/formoterol). It is essential to understand these risks and consult your healthcare provider with any questions or concerns.

• Paradoxical Bronchospasm: In rare cases, Symbicort can exacerbate symptoms of asthma or COPD by causing airway constriction, known as paradoxical bronchospasm, which can be life-threatening. Discontinue use immediately and contact your healthcare provider if you experience increased wheezing, shortness of breath, or coughing. Avoid using Symbicort during asthma attacks or severe episodes and do not exceed prescribed doses.

• Overdose Risks: Overuse of Symbicort, either in dosage or frequency, or concurrent use with another long-acting beta-agonist (LABA) like Striverdi Respimat (olodaterol), can lead to overdose. Seek immediate medical attention if you suspect an overdose or experience symptoms such as chest pain, rapid heartbeat, dizziness, headache, dry mouth, muscle cramps, nausea, or insomnia.

• Oral Thrush: The risk of developing fungal infections, such as thrush, in the mouth and throat increases without proper oral hygiene. Rinse your mouth after each use of Symbicort to prevent this. Symptoms include white patches, redness, or soreness in the mouth, and difficulty eating or swallowing. Contact your healthcare provider if you suspect thrush for appropriate treatment.

• Increased Infection Risk: Symbicort may reduce your immune system's ability to fight infections, including tuberculosis, chickenpox, and measles. Do not use Symbicort if you have an active or recurrent infection without consulting your healthcare provider. Notify them immediately if you show signs of infection, such as fever or sore throat.

• Steroid Transition Effects: Transitioning from oral to inhaled steroids can cause withdrawal symptoms due to changes in cortisol levels. Symptoms include nausea, fatigue, weakness, or muscle and joint pain. Ensure any steroid transition is managed by your healthcare provider.

• Adrenal Suppression: Long-term use may lead to adrenal suppression, where your body relies on steroid medication. Do not stop using Symbicort abruptly; consult your healthcare provider for guidance. Symptoms of withdrawal or adrenal suppression include fever, joint pain, and low energy in adults, or stunted growth and headaches in children.

• Cardiovascular Concerns: Excessive use of Symbicort can cause serious heart issues, seizures, or blood pressure changes. Avoid using with other LABA inhalers. Contact your healthcare provider if you experience chest pain, rapid heartbeat, or dizziness.

• Bone and Growth Risks: Long-term use may contribute to bone loss or poor growth. Those with a history of osteoporosis or fractures should discuss risks with their healthcare provider, who may monitor bone density.

• Eye Health: Prolonged use may increase eye pressure, exacerbate glaucoma, or cause cataracts. Report any vision changes to your provider promptly.

• Allergic Reactions: Individuals with allergies to budesonide should not use Symbicort. Symptoms of an allergic reaction include wheezing, dizziness, rash, or swelling of the tongue or throat. Seek immediate medical attention if these occur.

• Electrolyte Imbalance: Symbicort can cause temporary low potassium levels, affecting heart rhythm. Report symptoms like muscle pain or abnormal heartbeat to your healthcare provider.

Contraindications: Do not use Symbicort during asthma attacks or severe episodes of asthma or COPD without consulting your healthcare provider.

When using this medication, some common side effects may include headache, throat irritation, stomach upset, and symptoms of a common cold such as sore throat, headache, cough, and sneezing. These effects are generally mild but consult your healthcare provider if they persist or worsen. Additionally, some individuals might experience stuffy nose or upper respiratory tract infections.

This medication may also cause a rise in blood pressure, so monitoring it regularly is advised. In some cases, users have reported thrush, which is a yeast infection in the mouth or throat, as well as bronchitis, characterized by airway inflammation. While these are less common, they should still be discussed with your healthcare provider if they occur.

More severe side effects, though rare, require immediate medical attention. These include severe sudden worsening of breathing problems or asthma, chest pain, irregular heartbeat, severe dizziness, fainting, seizures, or a serious allergic reaction such as rash, swelling, or difficulty breathing. If you experience any of these symptoms, seek urgent medical care. Additionally, report any unusual symptoms not listed here to your healthcare provider for further advice.

When taking Symbicort (budesonide/formoterol), it's essential to be aware of potential interactions with other medications. Inform your doctor and pharmacist about all the medications and supplements you are currently using, including prescription and over-the-counter drugs, vitamins, and herbal products.

Certain medications should not be taken with Symbicort, as they can cause adverse interactions. These include Bepridil, Cisapride, Desmopressin, Dronedarone, Mesoridazine, Pimozide, Piperaquine, Saquinavir, Sparfloxacin, Terfenadine, Thioridazine, and Ziprasidone. If you are prescribed any of these, your doctor might choose an alternative treatment or adjust your existing medication plan.

Other drugs might be used with Symbicort, but with caution. If necessary, your doctor may adjust the dosages or usage frequency for medications such as Acebutolol, Amiodarone, Aripiprazole, and many others listed. This careful management helps to minimize potential risks while ensuring effective treatment.

In some cases, using Symbicort with specific medications like Auranofin, Erythromycin, and Ketoconazole can increase the likelihood of side effects. Nevertheless, your doctor might decide that the benefits of using both medications outweigh the risks, and they will monitor your treatment closely to adjust as needed. Always follow your healthcare provider's guidance when taking Symbicort with other medications.