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This document outlines essential safety information and warnings related to the use of phentermine (Adipex-P). It is crucial to review these details and discuss any questions or concerns with your healthcare provider.

• Avoid Combining with Other Weight Loss Drugs: The safety of using phentermine with other weight loss medications, including over-the-counter options, is not established. Consult your primary care provider before combining it with any other weight loss medication.

• Tolerance and Effectiveness: Over time, phentermine may become less effective, a condition known as tolerance. Increasing the dosage is not safe and can lead to serious side effects. Contact your primary care provider if you experience weight gain or increased appetite while on phentermine.

• Potential for Misuse and Dependence: Phentermine carries a risk of misuse and dependence similar to other stimulants. To mitigate these risks, it is typically prescribed in limited amounts. Use phentermine exactly as directed by your healthcare provider and discuss long-term weight management strategies with your care team.

• Impaired Concentration and Coordination: Phentermine can cause dizziness, trouble concentrating, and coordination issues. Avoid driving or engaging in tasks that require high focus until you understand how the medication affects you. Inform your healthcare provider if these side effects persist.

• Cardiovascular and Pulmonary Risks: There have been rare cases of pulmonary hypertension and heart valve problems in individuals using fen-phen, a combination that included phentermine. While these issues are unlikely with phentermine alone, report any symptoms like chest pain or shortness of breath to your provider immediately.

• Increased Blood Pressure Risk: Phentermine may raise blood pressure, so it's crucial to inform your provider if you have hypertension. Regular monitoring of your blood pressure may be required during treatment.

• Risk of Hypoglycemia in Diabetics: Diabetic patients using insulin or sulfonylureas such as glipizide may experience low blood sugar levels while taking phentermine. Adjustments to diabetes medications may be necessary, so consult your healthcare team.

Contraindications: Do not use phentermine if you have any of the following conditions or circumstances, as they pose significant health risks:

• Cardiovascular issues like stroke, irregular heartbeat, or uncontrolled hypertension.
• Overactive thyroid (hyperthyroidism).
• Glaucoma.
• Agitation or severe distress.
• History of substance use disorder.
• Pregnancy or breastfeeding.
• Recent use of monoamine oxidase inhibitors (MAOIs) within the last 14 days.
• Severe allergic reactions to amphetamine-based products.

Always consult your healthcare provider to ensure this medication is safe for you.

When taking this medication, you might experience some mild side effects such as dizziness, dry mouth, difficulty sleeping, irritability, nausea, vomiting, diarrhea, constipation, headache, or tremors. These effects are generally mild, but if they persist or worsen, consulting your healthcare provider is advisable. Additionally, this medication may cause an increase in blood pressure, so regular monitoring is recommended.

In some cases, individuals may experience more concerning side effects such as restlessness, behavioral changes, erectile dysfunction, or changes in sex drive. While these are less common, it’s important to contact your healthcare provider if they occur. Serious side effects, though rare, require immediate medical attention. These include severe headache, difficulty speaking, seizures, one-sided weakness, vision changes, and severe allergic reactions like rash, swelling, or trouble breathing.

This medication can also rarely lead to significant heart or lung issues, marked by symptoms such as chest pain, difficulty breathing, swelling of legs or ankles, and palpitations. If you experience these, it is crucial to stop taking the medication and seek emergency medical help. Monitoring for severely high blood pressure indicated by severe headache, chest pain, or confusion is also important, as is watching for symptoms of low blood sugar if applicable. Always prioritize seeking medical guidance if you notice any severe or unexpected side effects.

When taking this medication, it's important to be aware of potential interactions with other drugs. If you've used any appetite suppressants like Diethylpropion or ephedra/ma huang in the past year, inform your doctor before beginning this treatment. Combining this medication with MAO inhibitors (such as isocarboxazid, Linezolid, or Selegiline) can lead to severe, possibly fatal interactions. It's advised to avoid MAO inhibitors during treatment and wait at least two weeks after stopping them before starting this medication. Consult your doctor for guidance on when to safely start or stop taking these drugs.

This medication may also interact with high blood pressure medicines (like guanethidine), phenothiazines, or stimulants including amphetamines and certain street drugs. Additionally, notify your healthcare provider if you are using products that cause drowsiness, such as opioids, alcohol, or sleep aids, as these can amplify sedation effects.

Be cautious with over-the-counter products that may cause drowsiness or increase heart rate and blood pressure, such as certain cough and cold remedies. Caffeine can heighten the side effects of this medication, so limit your intake of caffeinated beverages and chocolate.

Lastly, this medication might interfere with some medical or lab tests, potentially leading to false results. Ensure all healthcare professionals involved in your care are informed about your medication use.