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Phentolamine is used primarily to manage and treat pheochromocytoma, a type of tumor that can cause high blood pressure. It is also used to prevent and control episodes of hypertension during surgery for pheochromocytoma. Additionally, phentolamine can be used to reverse soft tissue anesthesia, such as that caused by local anesthetics used in dental procedures.

Phentolamine injection is used to treat and prevent high blood pressure episodes during surgery. It is also used to diagnose pheochromocytoma, a type of tumor that can cause high blood pressure. Additionally, it can be used to reverse the effects of certain medications that cause constriction of blood vessels.

Phentolamine is an antidote for the extravasation of vasopressors, such as norepinephrine or dopamine, which can cause tissue necrosis. It is used to counteract the vasoconstrictive effects of these medications when they inadvertently leak into surrounding tissues.

Phentolamine in Trimix acts as a vasodilator. It works by relaxing blood vessels, which increases blood flow to the penis, aiding in the treatment of erectile dysfunction.

Phentolamine treats pheochromocytoma by blocking alpha-adrenergic receptors, which helps to counteract the effects of excessive catecholamines produced by the tumor. This action leads to vasodilation and a reduction in blood pressure, alleviating symptoms such as hypertension associated with pheochromocytoma.