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This medication carries important safety considerations that you should be aware of. Please review the following information carefully and discuss any concerns with your healthcare provider.

• Orthostatic Hypotension and Risk of Fainting: Prazosin (Minipress) may cause a significant drop in blood pressure when you stand up quickly from a sitting or lying position, potentially leading to dizziness or fainting. This risk is particularly notable after your first dose, when your dose is increased, or if another blood pressure medication is added to your regimen. You are most likely to experience dizziness within 90 minutes after taking a dose. Increased risk factors include being 65 years or older, taking other blood pressure medications, and consuming alcohol.

• Priapism: In rare instances, prazosin (Minipress) may lead to a painful erection lasting more than four hours, known as priapism. Immediate medical attention is required to avoid permanent erectile dysfunction.

• Intraoperative Floppy Iris Syndrome (IFIS): If you are undergoing cataract surgery and are taking prazosin (Minipress), inform your healthcare provider. This medication can occasionally cause changes to the iris during surgery, although it is less likely than other similar medications. You do not need to cease taking prazosin (Minipress) before surgery, but your surgeon should be informed to adjust the surgical technique accordingly.

Please consult your healthcare professional for further advice tailored to your individual circumstances and before making any changes to your medication regimen.

When taking this medication, some people may experience common side effects as their body adjusts. These can include headaches, dizziness, drowsiness, tiredness, weakness, nausea, vomiting, diarrhea, or constipation. It's not unusual to feel lightheaded or dizzy, particularly when standing up too quickly, especially during the first week of treatment. To minimize these effects, rise slowly from sitting or lying down. These symptoms are generally mild, but if they persist or worsen, it's advisable to consult a healthcare provider.

In some cases, individuals might experience more serious side effects such as a pounding heartbeat, fainting, frequent urination, mental or mood changes like depression, or swelling in the feet or ankles. These require prompt medical attention. Additionally, although rare, males may experience a painful or prolonged erection lasting more than four hours, known as priapism, which needs immediate medical intervention to prevent long-term damage.

Allergic reactions to this medication are uncommon, but if you experience symptoms such as a rash, severe dizziness, trouble breathing, or swelling, particularly of the face, tongue, or throat, seek medical help immediately. This is not an exhaustive list of possible side effects, and if you notice any other unusual symptoms, contacting a healthcare provider is recommended.

Prazosin (Minipress) can interact with a variety of medications and substances. It is important to inform your doctor and pharmacist about all the medications, including prescriptions, over-the-counter drugs, vitamins, and herbal supplements you are taking. Here are some important interactions to be aware of:

1. Alpha Blockers: Combining prazosin with other alpha blockers like doxazosin, terazosin, alfuzosin, silodosin, and tamsulosin is generally not advisable unless specifically directed by your doctor, as it may require adjustments in dosage or frequency of use.

2. Erectile Dysfunction and Pulmonary Hypertension Medications: Medicines such as sildenafil, tadalafil, and vardenafil can interact with prazosin, potentially increasing the risk of side effects. If used together, your doctor may need to modify the dosage or usage schedule.

3. Beta-Blockers: Using prazosin with beta-blockers like acebutolol, atenolol, bisoprolol, carvedilol, metoprolol, and propranolol, among others, might heighten the chances of side effects. However, it can sometimes be necessary for treatment, so dosage adjustments may be needed.

4. CNS Depressants and Alcohol: Be cautious with substances that cause drowsiness, such as opioid pain relievers (e.g., codeine, hydrocodone), alcohol, marijuana, sleep or anxiety medications (e.g., alprazolam, lorazepam), muscle relaxants, and antihistamines. These can amplify the sedative effects of prazosin.

5. Over-the-Counter Products and Supplements: Check with your pharmacist about any over-the-counter products, especially those for allergies, coughs, or colds, as they might contain ingredients that induce drowsiness or increase heart rate and blood pressure. This includes diet aids and NSAIDs like ibuprofen and naproxen.

Additionally, prazosin may interfere with certain laboratory tests, such as pheochromocytoma screening, potentially leading to inaccurate results. Ensure that all healthcare providers and lab personnel are aware that you are taking this medication.