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This document outlines crucial safety and warning information regarding the use of Poly Hist Forte, containing doxylamine and phenylephrine. Please read thoroughly and discuss any concerns with your healthcare provider.

• Drowsiness: Doxylamine may cause significant drowsiness, potentially impairing your ability to concentrate, think, or respond. This risk is heightened if you are aged 65 or older, consume alcohol while taking this medication, or use other sedative drugs such as opioids, benzodiazepines, or sleep aids. Refrain from driving or operating heavy machinery until you understand how the medication affects you. Risk factors include alcohol consumption, concurrent use of sedative medications, and age 65 or older.

• Exacerbation of Medical Conditions: Poly Hist Forte may aggravate certain pre-existing medical conditions. This medication might be unsuitable if you have conditions such as glaucoma, high blood pressure, thyroid disorders, diabetes, respiratory issues, or urinary problems. Additionally, it may not be safe if you are currently using medications like opioids or other antihistamines and decongestants. Ensure you inform your healthcare provider about all your medical conditions to assess the safety of this medication. Risk factors include glaucoma, heart disease or hypertension, thyroid disorders, high blood sugar, respiratory problems, and urinary issues.

• Accidental Overdose: This medication contains both an antihistamine (diphenhydramine) and a decongestant (phenylephrine), which are common in many over-the-counter products. Using multiple medications with these ingredients can result in an accidental overdose, which may be life-threatening.

• Contraindications: Do not use this medication if you are currently taking or have recently taken a monoamine oxidase inhibitor (MAOI) within the last two weeks, as this may pose serious health risks. Always consult your healthcare provider before taking this medication if this applies to you.

In case of an overdose or if you experience severe side effects, seek emergency medical attention immediately.

When taking this medication, you might experience some common side effects such as drowsiness, dizziness, and dry mouth, nose, or throat. These are generally mild, but if they persist or worsen, it's advisable to reach out to a healthcare provider. Other side effects may include headaches, an upset stomach, constipation, and trouble sleeping. While these are usually not serious, you should monitor them and consult a professional if needed.

There are also some side effects that require more immediate attention. These include mental or mood changes like confusion or hallucinations, ringing in the ears, difficulty urinating, and vision changes such as blurred or double vision. If you encounter any of these, it's important to contact a healthcare provider promptly.

In rare cases, very serious side effects can occur, such as a fast or irregular heartbeat or seizures. These situations demand urgent medical assistance. Additionally, although rare, serious allergic reactions can happen. Signs of an allergic reaction include rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, and trouble breathing. If you notice any of these symptoms, seek medical help immediately. This summary doesn't cover all potential side effects, so if you experience anything unusual, it's best to consult your healthcare provider.

Certain medications and products may interact with this drug, leading to serious consequences. Topical antihistamines, such as diphenhydramine cream, ointment, or spray, can interact with this medication. Additionally, using MAO inhibitors alongside this drug can result in a potentially fatal reaction. Therefore, you should avoid taking MAO inhibitors, including isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, and tranylcypromine, while on this medication. It's crucial to consult with your doctor about when to begin or discontinue these treatments, as most MAO inhibitors should not be used for at least two weeks before starting this drug.

Inform your healthcare provider if you are using other substances that induce drowsiness, such as opioid pain or cough medications (e.g., codeine, hydrocodone), alcohol, marijuana, sleep or anxiety medications (e.g., alprazolam, lorazepam, zolpidem), muscle relaxants (e.g., carisoprodol, cyclobenzaprine), or other antihistamines (e.g., cetirizine, diphenhydramine). Be sure to read the labels on all your medications, especially those for allergies or colds, as they may contain ingredients that cause drowsiness. Consult your pharmacist to ensure safe usage.

This medication may also affect the results of certain medical or laboratory tests, such as brain scans for Parkinson's disease, urine drug screenings, and allergy skin tests, potentially leading to false outcomes. Notify all healthcare professionals and lab personnel involved in your care about your use of this medication.