Povidone-iodine

Drug Details

Povidone-iodine (PVP-I) is a widely used antiseptic that combines iodine with the water-soluble polymer polyvinylpyrrolidone, enhancing iodine's stability and reducing tissue irritation. Upon application, PVP-I releases free iodine, which penetrates microbial cell walls, disrupting proteins and nucleic acids, leading to the death of a broad spectrum of pathogens, including bacteria, viruses, fungi, and protozoa. This broad antimicrobial activity makes PVP-I effective for various medical uses, such as preoperative skin preparation, wound treatment, and infection control in surgical settings. It is available in multiple formulations, including solutions, ointments, and surgical scrubs, typically at concentrations ranging from 7.5% to 10%. While generally well-tolerated, PVP-I can cause skin irritation in some individuals and is contraindicated in those with known iodine hypersensitivity or thyroid disorders.