Premphase

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Prempro is a prescription medication that combines estrogen and progestin hormones to help alleviate menopausal symptoms such as hot flashes and vaginal dryness. It is also used to prevent osteoporosis in postmenopausal women. This hormone replacement therapy is specifically for individuals with a uterus, as the progestin component helps reduce the risk of uterine cancer, which can be increased by estrogen alone. Women who have had a hysterectomy do not require the progestin component and should avoid this combination therapy. Prempro is taken orally once daily, with the same dosage each day. An alternative, Premphase, involves a regimen of two types of tablets: one containing estrogen alone and the other a combination of estrogen and medroxyprogesterone, taken on different days. While Prempro can effectively manage moderate-to-severe vasomotor symptoms like hot flashes and night sweats, as well as moderate-to-severe vaginal symptoms, there are other medications available that may be considered for osteoporosis prevention, such as raloxifene or bisphosphonates like alendronate. Common side effects of Prempro include breast pain, headaches, and menstrual cramps. It's important to follow your healthcare provider's instructions regarding dosage and to discuss any concerns or side effects with them. Always consult healthcare professionals before starting any new treatment regimen.
Our Premphase coupons are free to use. You can print the coupon, email it to yourself, or receive the Premphase coupon via text message. To get your free discount, show the pharmacist your Premphase savings card which has the discounted coupon price. Use our filters below to edit the prescription box to match your needs. The Premphase prices will update based on your prescription needs. Above our Premphase coupons, you can change the location to see pharmacy prices in other areas. Our prescription discount card will update online with the specific pharmacy costs associated with your edits. Be sure to text, email, or print the Premphase savings card code that you need after editing the prescription box and location field. Show the discount card to your pharmacist before paying.

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0.625-5MG, Premphase (30 Tablets)

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CVS

$256.81

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$255.24

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$256.39

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$267.38

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Premphase dosage forms

The average cost for 30 Tablets of Premphase at 0.625-5MG is $253.21 with a free coupon. This is 27.24% off the average retail price of $929.65
DosageQuantityPrice fromPer unit
0.625-5MG30 Tablets$253.21$8.44

Premphase Warnings

This medication, containing estrogens and progestins, requires careful consideration due to potential risks and side effects. It is important to regularly consult with your healthcare provider to discuss whether the benefits of this treatment outweigh the risks in your specific case. Below are key safety warnings and precautions associated with its use:

  • Blood Clots: The use of this medication can increase the risk of serious blood clots, which can be life-threatening. Be vigilant for symptoms such as unexplained swelling, pain in the limbs, or difficulty breathing, and seek immediate medical attention if they occur. The risk is higher for those over 50, individuals with high blood pressure, obesity, high cholesterol, diabetes, a history of smoking, or recent surgery.

  • Breast and Uterine Cancer: Prolonged use of hormone replacement therapy can elevate the risk of breast and uterine cancer. Regular breast examinations and mammograms are advised. Report any unusual changes or bleeding to your healthcare provider promptly. The risk increases if there is a personal or family history of breast cancer or if the medication is used for more than a year.

  • Dementia: There is a potential increased risk of dementia with this medication, especially if initiated after age 65. Discuss your risk factors with your healthcare provider.

  • Gallbladder and Liver Issues: This medication may cause gallbladder complications or liver problems. Symptoms such as persistent stomach pain, nausea, jaundice, or fever should be reported to your healthcare provider immediately.

  • Calcium Imbalance: Individuals with a history of breast cancer that has metastasized to bones may experience high calcium levels. Monitor for symptoms like excessive thirst, abdominal pain, or confusion and inform your healthcare provider if they occur.

  • Vision Problems: Rarely, vision issues may arise due to blood clots in the eyes. Seek immediate medical care if you experience sudden vision changes or migraines.

  • High Triglycerides: Estrogens can increase triglyceride levels, potentially leading to heart problems or pancreatitis. Regular blood tests might be necessary to monitor this risk.

  • Thyroid and Fluid Retention: This medication can alter thyroid hormone levels, necessitating adjustments in thyroid medication. It may also cause fluid retention, particularly affecting individuals with heart or kidney conditions. Report any unusual swelling or rapid weight gain to your healthcare provider.

  • Severe Allergic Reactions: Though rare, severe allergic reactions can occur. Symptoms such as difficulty breathing, hives, or swelling warrant immediate emergency care.

  • Exacerbation of Pre-existing Conditions: Inform your healthcare provider about any pre-existing conditions such as high blood pressure, asthma, diabetes, or migraines, as this medication may worsen these conditions.

Contraindications: This medication should not be used if you have undiagnosed abnormal genital bleeding, a history of estrogen-dependent cancer, blood clotting disorders, liver problems, or if you are currently pregnant.

Always discuss any concerns or symptoms with your healthcare provider to ensure safe and effective use of this medication.

Premphase Side Effects

When taking this medication, you may experience common side effects such as breast tenderness, headaches, stomach discomfort, menstrual cramps, gas, nausea, depression, and increased vaginal discharge. These effects are usually mild, but if they persist or worsen, it's important to consult your healthcare provider for guidance.

There are also other side effects that have been reported, which include back pain, weakness, dizziness, migraines, itching, breast growth, vaginal pain, and weight gain. While these are less common, you should still inform your healthcare provider if you experience any of them, especially if they are severe.

Serious side effects, though rare, require prompt medical attention. These include severe allergic reactions characterized by swelling of the tongue or throat, breathing difficulties, and rashes. Additionally, symptoms of a heart attack, such as chest pain or pain radiating to the shoulder, arm, neck, or jaw, and signs of a stroke, such as sudden trouble speaking, walking, or numbness on one side of the body, should be addressed immediately. Blood clots may present as chest pain, shortness of breath, dizziness, fast heart rate, and swelling or redness in the limbs. Furthermore, be vigilant for signs of cancer, including lumps, changes in the breasts, swollen lymph nodes, unusual vaginal bleeding, extreme tiredness, and unexplained stomach pain.

Always be attentive to how your body responds to the medication and seek medical advice if you notice any concerning symptoms.

Premphase Interactions

When using Prempro, be aware that it may interact with certain medications. Inform your doctor and pharmacist about all the medications and supplements you are currently taking, including prescription, over-the-counter, vitamins, and herbal products. Some medications, like tranexamic acid, should not be used with Prempro. Others, such as amifampridine, apalutamide, and several others, are generally not recommended but might be necessary in some cases. If both medicines are needed, your doctor may adjust the dosage or frequency. Additionally, some drugs like etoricoxib and levothyroxine might increase the risk of side effects when used with Prempro, but they may still be prescribed together if they provide the best treatment option. Prempro may also interfere with certain lab tests, which could lead to inaccurate results. Ensure all healthcare providers are aware that you are taking Prempro.
Premphase FAQs
What is PREMPHASE used for?

Premphase is used for hormone replacement therapy in postmenopausal women. It helps manage symptoms associated with menopause, such as hot flashes and vaginal dryness, and also helps in the prevention of osteoporosis.

PREMPHASE contains two active ingredients: conjugated estrogens and medroxyprogesterone acetate. Conjugated estrogens are a mixture of estrogen hormones, and medroxyprogesterone acetate is a progestin. These ingredients are used in combination for hormone replacement therapy.

PREMPHASE is indicated for the treatment of moderate to severe vasomotor symptoms associated with menopause, as well as for the prevention of postmenopausal osteoporosis. It is a hormone replacement therapy that combines conjugated estrogens with medroxyprogesterone acetate.

PREMPHASE is a hormone replacement therapy that consists of two active ingredients: conjugated estrogens and medroxyprogesterone acetate. It is typically used to treat symptoms associated with menopause.

Premphase is a hormone replacement therapy that combines conjugated estrogens and medroxyprogesterone acetate. It is primarily used to treat symptoms associated with menopause, such as hot flashes, vaginal dryness, and prevention of osteoporosis. By supplementing estrogen and progestin, it helps alleviate these symptoms and supports bone health in postmenopausal women.