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When considering the use of estrogen or estrogen/progestin therapies, it is crucial to be aware of the potential risks and precautions associated with these treatments. Below is a comprehensive overview of important safety information and warnings:

• Risk of Serious Side Effects: Estrogen alone or combined with progestin can lead to severe health issues such as heart disease, strokes, and blood clots. The risk is heightened if you or your family have a history of these conditions, or if you have high blood pressure, diabetes, or use tobacco.

• Breast and Other Cancers: Taking estrogen/progestin therapies may increase the risk of breast, ovarian, and uterine cancers. This risk is greater with long-term use. Regular breast exams and mammograms are recommended to monitor for any changes.

• Dementia Concerns: Women over 65 using these therapies might have an elevated risk of dementia. These treatments are not recommended for dementia prevention.

• Liver, Gallbladder, and Calcium Issues: Estrogen can lead to liver or gallbladder disease and alter calcium levels, particularly impacting those with a history of liver disease or breast cancer.

• Vision and Thyroid Changes: Rarely, estrogen use can cause vision problems and affect thyroid hormone levels, necessitating adjustments in thyroid medication.

• Fluid Retention and Worsening Conditions: Estrogen/progestin therapies might cause fluid retention, exacerbating existing heart or kidney conditions. They can also worsen asthma, migraines, seizures, diabetes, lupus, and liver problems.

• Contraindications: Avoid these therapies if you have undiagnosed vaginal bleeding, a history of breast cancer, blood clots, heart attack, stroke, or liver disease, or if you are pregnant.

• Regular Monitoring and Consultation: Use the lowest effective dose for the shortest time possible. Regular check-ups and physical exams are advised to evaluate the necessity of continued use.

In the event of overdose or if serious side effects occur, seek immediate medical attention. Always discuss with a healthcare provider to ensure these therapies are suitable for your specific health needs.

When using this medication, some common side effects may occur, typically mild in nature. These include stomach discomfort, nausea, vomiting, bloating, headache, breast tenderness, and weight fluctuations. If these symptoms persist or worsen, it is advisable to consult your healthcare provider.

More serious side effects, though less common, require prompt medical attention. These include persistent nausea or vomiting, mental or mood changes such as depression or memory loss, breast lumps, unusual changes in vaginal bleeding, increased vaginal irritation or discharge, severe abdominal pain, yellowing of the skin or eyes, dark urine, and swelling of the hands, ankles, or feet. Additionally, symptoms such as increased thirst or urination could indicate more severe issues.

Rare but severe side effects include blood clots, which may present as trouble breathing, leg pain or swelling, and warm skin. Heart attack symptoms include chest pain, arm pain, and shortness of breath, while signs of a stroke include sudden weakness on one side of the body and confusion. Other serious conditions to be aware of include uterine or ovarian cancer, indicated by unusual vaginal bleeding and pelvic pain, and breast cancer, signified by breast lumps or changes. Abnormal calcium levels, presenting as tiredness, muscle issues, and tingling sensations, also require immediate attention.

Lastly, although rare, an allergic reaction to this medication may occur, with symptoms such as rash, itching, swelling of the face, tongue, or throat, severe dizziness, and difficulty breathing. If you experience these symptoms, seek medical help immediately. Always report any additional side effects to your healthcare provider.

Femhrt (ethinyl estradiol / norethindrone) can interact with a range of medications, which may affect its effectiveness or increase the risk of side effects. It is crucial to inform your doctor and pharmacist about all the medications and supplements you are taking, including over-the-counter drugs, vitamins, and herbal products.

Some drugs should not be used with Femhrt, such as aromatase inhibitors (Anastrozole, Exemestane, Letrozole), fezolinetant, Fulvestrant, ospemifene, Raloxifene, Tamoxifen, Toremifene, and Tranexamic Acid. These interactions may alter the way Femhrt works or increase the risk of side effects.

Additionally, Femhrt may interfere with specific laboratory tests, like the metyrapone test, potentially leading to inaccurate results. Therefore, it's important to inform all healthcare providers and laboratory personnel that you are taking Femhrt.

In some situations, using Femhrt with other medications, such as dasabuvir, ombitasvir, paritaprevir, Ritonavir, or tranexamic acid, is typically not advised. However, if your doctor deems it necessary, they may adjust the dosage or frequency of these medications.

Lastly, some medicines may increase the risk of side effects when taken with Femhrt, but their combination might be necessary for treatment. In such cases, your doctor will carefully monitor your therapy and may adjust the dosages accordingly. Always consult your healthcare provider for guidance on managing potential drug interactions.