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This medication comes with several important safety warnings and precautions to ensure its safe use. Please review the following information carefully and consult your healthcare provider if you have any questions or concerns.

• Masking of Serious Conditions: Frequent heartburn might be a sign of more serious conditions such as stomach cancer. If your heartburn worsens or reoccurs after taking lansoprazole (Prevacid), or if you experience poor appetite, unexplained weight loss, or weakness, contact your provider promptly.

• Sudden Kidney Issues: Lansoprazole (Prevacid) may cause sudden kidney problems at any point during treatment. If you experience abnormal urination, nausea, weakness, fever, rash, or joint pain, consult your healthcare provider as these could be signs of kidney issues.

• Severe Diarrhea from Infections: There is an increased risk of a bacterial infection called Clostridioides difficile (C. diff) when taking lansoprazole (Prevacid), especially in individuals over 65, those with recent hospital or nursing home stays, or with weakened immune systems. If severe diarrhea, fever, abdominal pain, loss of appetite, or nausea occur, seek medical advice immediately.

• Bone Fracture Risk: Extended use or high doses of lansoprazole (Prevacid) may increase the risk of bone fractures, particularly in the hip, wrist, or spine. Discuss your risk with your provider if you have a history of osteoporosis or bone fractures.

• Serious Skin Reactions: Rare but severe skin reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis, have been reported. Immediate medical attention is required if you have a fever, body aches, rash, peeling skin, blisters, or facial swelling.

• Lupus Symptoms: Some users of lansoprazole (Prevacid) may develop or worsen lupus, characterized by joint pain or rash. If these symptoms occur, discontinue use and contact your healthcare provider.

• Deficiency in Vitamin B12 and Magnesium: Long-term use of lansoprazole (Prevacid) can lower vitamin B12 and magnesium levels. If you've used this medication for over three years or notice symptoms like dizziness, muscle weakness, pale skin, fatigue, or tingling, consult your provider.

• Drug Interactions: Certain medications, such as St. John’s Wort and rifampin, can reduce the effectiveness of lansoprazole (Prevacid). Avoid these while on this medication and discuss any potential interactions with your healthcare provider.

• Phenylketonuria (PKU) Consideration: The orally disintegrating tablets of lansoprazole (Prevacid) contain phenylalanine, which is harmful to individuals with PKU. If you or your child has PKU, opt for the capsule form and verify with your healthcare provider which formulation is safe.

Contraindications:

• Do not use this medication if you have a known allergy to proton pump inhibitors (PPIs).
• Avoid use if you are taking Edurant (rilpivirine) or medications containing rilpivirine, such as Complera, due to potential serious health risks.

In case of overdose, seek emergency medical attention immediately.

When using this medication, some common side effects might occur. These include mild issues like diarrhea and abdominal pain, which typically resolve on their own. However, if they persist or worsen, it's advisable to consult a healthcare provider for guidance. Other mild effects such as nausea or constipation have also been reported. These effects are generally not serious, but seeking advice is recommended if they become bothersome.

On the other hand, certain rare but serious side effects require immediate medical attention. Severe stomach pain or persistent diarrhea could signal a more significant issue and should not be ignored. In some cases, this medication may cause kidney problems, indicated by changes in urination, such as urinating more or less than usual, or experiencing pain or fever during urination. Additionally, symptoms of lupus such as joint pain or a rash that worsens in sunlight should be urgently addressed.

There is also a rare risk of a severe allergic reaction, which may present as blistering, peeling skin, fever, or chills. Immediate medical care is crucial if these symptoms appear. Long-term use of this medication may lead to vitamin B-12 deficiency, with symptoms like unusual weakness or tingling in the hands and feet, which should be discussed with a healthcare provider. Always stay vigilant and consult with a healthcare professional if you notice any unexplained or severe symptoms.

Lansoprazole, also known as Prevacid, can interact with several other medications. It's important to inform your doctor and pharmacist about all medications and supplements you are taking, including prescription, over-the-counter, vitamins, and herbal products.

One specific medication to avoid while using lansoprazole is rilpivirine, as its combination is not recommended. Additionally, lansoprazole may alter the effectiveness of medications that require stomach acid for proper absorption, such as ampicillin, atazanavir, erlotinib, nelfinavir, and certain antifungal drugs like itraconazole, ketoconazole, and posaconazole. It can also interact with drugs like methotrexate, especially in high doses, potentially increasing the risk of side effects.

Lansoprazole is similar to dexlansoprazole, so they should not be used together. Furthermore, lansoprazole might affect the results of certain laboratory tests, leading to false outcomes. Therefore, it's essential to inform lab personnel and your healthcare providers that you are using this medication.