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Below are important safety and warning details concerning the use of Priftin (rifapentine). It is crucial to understand these risks and take necessary precautions. Always consult your healthcare provider if you have any questions or concerns.

• Liver Injury: Priftin may elevate liver enzymes, indicating potential liver damage. Refrain from consuming alcohol and any other liver-harming medications. Inform your doctor if you have a history of liver issues, as regular blood tests may be necessary to monitor liver health. Seek immediate medical attention if you experience severe nausea, vomiting, right-sided stomach pain, fatigue, loss of appetite, or yellowing of the skin or eyes.

• Severe Allergic Reaction: There is a risk of severe allergic reactions, including potentially life-threatening conditions like facial swelling and anaphylaxis. Discontinue use and seek emergency medical care if you develop a rash, facial or lip swelling, or difficulty breathing.

• Severe Skin Reaction: Serious skin reactions such as Stevens-Johnson syndrome (SJS) and drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome may occur. Stop taking Priftin and get medical help if you notice skin changes, such as rash, painful blisters, redness, peeling, or mouth sores. Also, seek prompt medical attention if you experience a sore throat, fever, or fatigue.

• Red-Orange Discoloration: Priftin can cause your bodily fluids, such as urine, sweat, saliva, or tears, and tissues like skin, tongue, or teeth to turn a red-orange color. This is harmless to your health but may permanently stain contact lenses or dentures.

• Diarrhea from Clostridioides difficile Infection: The use of antibiotics, including Priftin, can disrupt normal gut bacteria, potentially leading to an overgrowth of Clostridioides difficile (C. diff) and causing life-threatening diarrhea.

Contraindications: Priftin should not be used if you have allergies to Priftin itself, or related antibiotics such as rifampin (Rifadin), rifaximin (Xifaxan), or rifabutin (Mycobutin). If you have such allergies, consult your healthcare provider before using this medication.

When taking this medication, some common side effects you might experience include stomach upset, nausea, vomiting, loss of appetite, and headaches. These are usually mild and may resolve on their own, but consult your healthcare provider if they persist or worsen. Additionally, you may notice harmless changes such as reddish urine, sweat, saliva, or tears, though dentures and contact lenses might be permanently stained.

Occasionally, individuals may experience low blood cell counts, coughing, sweating, or elevated liver enzymes. While these effects are less common, it's important to inform your healthcare provider if they occur. In rare cases, more severe side effects can arise, including symptoms of liver disease like persistent nausea, vomiting, unusual tiredness, severe stomach pain, yellowing of the eyes or skin, and dark urine. Also, watch for signs of a severe intestinal condition linked to C. difficile, such as persistent diarrhea, abdominal pain, or blood in your stool.

A very serious allergic reaction is rare but requires immediate medical attention. Symptoms include persistent fever, swelling of lymph nodes, rash, itching, swelling of the face, tongue, or throat, severe dizziness, and difficulty breathing. If you notice any side effects not listed here, it's advisable to contact your healthcare provider. Remember, while side effects can occur, many people use this medication without serious issues.

Rifapentine can accelerate the elimination of certain medications from your body, potentially reducing their effectiveness. This includes drugs like Digoxin, Phenytoin, ranolazine, Tacrolimus, blood thinners such as Warfarin, and calcium channel blockers like diltiazem and Verapamil. It can also affect some HIV medications, including NNRTIs like etravirine and Nevirapine, and protease inhibitors such as Atazanavir and Darunavir.

This medicine can decrease the efficacy of hormonal birth control methods like pills, patches, or rings, possibly leading to unintended pregnancy. It's important to discuss with your healthcare provider whether you should use an additional form of birth control while taking this medicine. If you notice unusual spotting or breakthrough bleeding, inform your doctor as these might indicate your birth control is less effective.

Additionally, rifapentine may interfere with certain laboratory tests, potentially causing inaccurate results, particularly for folate and Vitamin B12 levels. Ensure that all medical professionals involved in your care are aware that you are taking this medication.

Please consult with your healthcare provider about all other medications, including over-the-counter drugs and supplements, you are using to prevent potential interactions. Some drugs should not be combined with rifapentine, while others may require dose adjustments or special monitoring. Always follow your doctor’s guidance on managing these interactions.