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The safety information below outlines important risks and precautions associated with the use of hydrocortisone (Anusol-HC). It is crucial to follow these guidelines and consult your healthcare provider if you have any questions or concerns.

• Hormone Imbalance and Withdrawal: Prolonged use of hydrocortisone (Anusol-HC) may lead to adrenal suppression, a condition where the body reduces its natural steroid hormone production. Abruptly stopping the medication can cause withdrawal symptoms such as dizziness, fatigue, and nausea. To mitigate these risks, your healthcare provider may conduct a rectal exam to ensure the medication is appropriate for you. Do not discontinue the use of hydrocortisone (Anusol-HC) without medical advice. Increased risk factors include extended usage, excessive application, and covering the treated area with a bandage, particularly in young children.

• Infection Risks: Extended use of hydrocortisone (Anusol-HC) can increase the likelihood of fungal or bacterial infections. Avoid using this medication if you have an existing skin infection, as it may exacerbate the condition. Notify your healthcare provider if you experience redness, swelling, pain, pus, or if symptoms persist beyond seven days, as these may indicate a new infection.

• Skin Reactions: Overuse of hydrocortisone (Anusol-HC) can cause skin irritation, including thinning, stretch marks, spider veins, burning, itching, dryness, inflamed hair follicles, changes in skin color, or rash. Your provider will assess whether this medication is suitable for you through a rectal exam to prevent severe reactions. Report any new or worsening skin issues to your healthcare provider promptly. Risks are higher with excessive and improper use of the medication.

Ensure you adhere to the recommended dosage and guidelines provided by your healthcare provider to minimize potential risks.

When using this medication, some common side effects may include redness, burning, itching, or irritation at the application site. These are typically mild and should subside over time. If they persist or worsen, it is advisable to consult your healthcare provider for guidance. Additionally, some users might experience dry skin or changes in skin texture, such as thinning or stretch marks. Acne-like bumps, inflamed hair follicles, or increased hair growth can also occur, alongside potential alterations in skin color or appearance.

In more serious cases, although rare, side effects like rectal bleeding, signs of infection (such as a persistent sore throat or fever), and changes in skin thickness or color may arise. Immediate medical attention is necessary if these symptoms develop. There is a remote chance of the medication being absorbed into the bloodstream, which could cause symptoms of excessive corticosteroid presence, including unusual tiredness, weight loss, headaches, swelling of the ankles or feet, increased thirst and urination, and vision problems.

A very serious allergic reaction to this drug is rare but requires immediate emergency assistance if symptoms such as rash, severe dizziness, trouble breathing, or swelling of the face, tongue, or throat occur. Always monitor your body's response to the medication and communicate any concerns with your healthcare provider to ensure safe and effective use.