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REXTOVY is a nasal spray containing naloxone hydrochloride, used to counteract opioid overdoses. While it can be life-saving, it's important to be aware of certain risks associated with its use.

Risk of Recurrent Respiratory and Central Nervous System Depression

The effects of REXTOVY may wear off before the opioids in the system are fully cleared. This means that after an initial improvement, the person could relapse into respiratory or central nervous system depression. Therefore, it's crucial to seek emergency medical assistance immediately after administering REXTOVY and to keep the individual under continuous observation. Additional doses may be necessary if the person does not respond adequately or if symptoms return.

Limited Efficacy with Certain Opioids

REXTOVY may not fully reverse the effects of partial agonists or mixed agonist/antagonist opioids, such as buprenorphine and pentazocine. These substances bind differently to opioid receptors, potentially requiring higher or repeated doses of naloxone for effective reversal. In such cases, the onset of reversal may be gradual, and the duration of action may be shorter than expected.

Precipitation of Severe Opioid Withdrawal

In individuals dependent on opioids, administering REXTOVY can trigger sudden and intense withdrawal symptoms. These may include body aches, diarrhea, rapid heartbeat, fever, runny nose, sneezing, goosebumps, sweating, yawning, nausea or vomiting, nervousness, restlessness or irritability, shivering or trembling, abdominal cramps, weakness, and increased blood pressure. In newborns, withdrawal can be life-threatening if not promptly recognized and treated, with signs such as seizures, excessive crying, and hyperactive reflexes. It's essential to monitor the individual for these symptoms and manage them appropriately.

Cardiovascular Risks

In some cases, especially in individuals with pre-existing heart conditions or those who have taken medications with similar cardiovascular effects, the use of naloxone has been associated with serious heart-related events. These can include low or high blood pressure, irregular heart rhythms, pulmonary edema (fluid in the lungs), and even cardiac arrest. Such events have, in rare instances, led to death, coma, or brain damage. Therefore, after administering REXTOVY, it's important to monitor the person closely for any signs of cardiovascular distress.

Hypersensitivity Reactions

REXTOVY is contraindicated in individuals known to be hypersensitive to naloxone hydrochloride or any other ingredients in the formulation. Hypersensitivity reactions can include symptoms such as rash, swelling, or difficulty breathing. If an allergic reaction is suspected, seek immediate medical attention.

In summary, while REXTOVY is a critical tool in reversing opioid overdoses, it's vital to be aware of these risks and to ensure that emergency medical care is sought immediately after its use.

Rextovy (naloxone hydrochloride) is a medication used for the emergency treatment of known or suspected opioid overdose. While it is generally safe and effective, it's important to be aware of potential interactions with other substances and medical conditions.

Drug Interactions:

Rextovy may interact with certain medications, which can affect its effectiveness or increase the risk of adverse effects. Notably, it has interactions with 30 different drugs, including one major, 27 moderate, and two minor interactions. These interactions can vary depending on the specific medications involved. Therefore, it's crucial to inform your healthcare provider about all prescription and over-the-counter medications, vitamins, and herbal supplements you are currently taking.

Disease Interactions:

In addition to drug interactions, Rextovy has four known disease interactions. These interactions can influence how the medication works or increase the risk of side effects. It's essential to discuss your complete medical history with your healthcare provider to ensure Rextovy is safe and appropriate for you.

Important Considerations:

• Emergency Use: Rextovy is intended for emergency situations involving opioid overdose. It is not a substitute for professional medical care. After administering Rextovy, seek immediate medical attention.

• Withdrawal Symptoms: In individuals dependent on opioids, the use of Rextovy can precipitate acute withdrawal symptoms. These may include body aches, fever, sweating, runny nose, sneezing, goosebumps, yawning, weakness, shivering or trembling, nervousness, restlessness or irritability, diarrhea, nausea or vomiting, stomach cramps, fast heartbeat, and increased blood pressure. Be prepared for these potential reactions and consult healthcare professionals promptly.

Always consult with your healthcare provider before using Rextovy, especially if you have underlying health conditions or are taking other medications. They can provide personalized advice and ensure that Rextovy is used safely and effectively in your specific situation.