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The following safety information outlines potential risks and essential precautions when using this medication. Carefully review these warnings and consult your healthcare provider if you have any questions or concerns.

• Opioid Withdrawal: Naloxone may induce sudden opioid withdrawal or reveal underlying pain in individuals who regularly use opioids or have received them during surgery. Symptoms include general pain, abdominal pain, diarrhea, rapid heart rate, fever, sweating, nausea, vomiting, irritability, and trembling. For infants, symptoms can be life-threatening, potentially causing seizures, excessive crying, and abnormal reflexes. Immediate medical attention is required if these symptoms occur after naloxone administration. High-risk groups include regular opioid users, infants under one month who have received opioids, and individuals undergoing opioid-related surgery.

• Worsening Opioid Overdose Symptoms: Although naloxone can initially improve opioid overdose symptoms, these may worsen as the medication's effects diminish after 30 to 90 minutes, while opioids may remain in the system longer. Always seek emergency medical assistance during an overdose and remain with the person until help arrives, even if symptoms appear to improve. This is crucial for individuals using long-acting opioids.

• Limited Effectiveness with Certain Opioids: Naloxone's efficacy may be reduced in individuals taking opioids with mixed receptor activities, such as buprenorphine. Multiple naloxone doses might be necessary to counteract these medications. Ensure each dose is administered using a new device or nasal spray. This warning is particularly relevant for those using pain medications containing buprenorphine or pentazocine.

• Heart Problems: Patients with a history of heart issues or those on heart-affecting medications should inform their healthcare provider before surgeries involving opioid use. Naloxone, often used post-surgery to reverse opioid effects, can lead to serious cardiac complications, including seizures, irregular heartbeat, pulmonary edema, or blood pressure changes. Rarely, it may cause neurological issues, coma, or death. Discuss your medical history with your provider if you have upcoming surgery.

Please note there are no listed contraindications for this medication.

When using this medication, some individuals may experience common side effects such as nasal dryness, congestion, or swelling. These are generally mild and should not be cause for alarm unless they persist. Muscle or joint pain, along with headaches, may also occur but are typically manageable. Additionally, a temporary increase in blood pressure might be noticed, which usually resolves on its own.

In some cases, users might report nausea or feelings of dizziness and lightheadedness. These effects are usually mild but should be monitored. If any of these symptoms continue or worsen, it is advisable to consult a healthcare professional.

There are rare but serious side effects that require immediate medical attention. These include constipation, stomach pain, toothache, and muscle spasms. An allergic reaction, although uncommon, could manifest as a rash, severe dizziness, or difficulty breathing. If any signs of a severe allergic reaction appear, it is crucial to seek urgent medical care.

For individuals regularly using opioids, withdrawal symptoms such as body aches, fever, and increased heart rate may occur suddenly. In infants under four weeks, sudden opioid withdrawal can be life-threatening, presenting as seizures or excessive crying. Always remain vigilant for these symptoms and seek prompt medical attention if they arise.