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This medication is designed to help manage irregular heartbeats, but it is important to be aware of potential side effects and necessary precautions. Discuss any concerns with your healthcare provider.

• Risk of Death: In rare instances, propafenone (Rythmol) may increase the risk of death, particularly in individuals with ventricular arrhythmias or those who have recently experienced a heart attack. It should only be prescribed if your condition is considered life-threatening. Consult your heart specialist about any concerns.

• Abnormal Heart Rhythm: The medication may exacerbate abnormal heart rhythms, whether too fast or too slow, which can be life-threatening. Regular follow-ups with your provider, including EKGs, are essential. Seek immediate medical help if you experience symptoms like chest pain, dizziness, or fainting.

• Drug Interactions: Propafenone can interact adversely with many medications and substances like grapefruit juice and tobacco, potentially leading to dangerous heart rhythms. Inform your healthcare providers about all medications and substances you use.

• Heart Failure: The medication can cause new or worsening heart failure. Notify your provider if you experience symptoms such as unexplained weight gain or swelling in the legs.

• Heart Devices: If you have a pacemaker or defibrillator, propafenone may affect its function. Regular checkups are necessary to ensure proper device adjustment.

• Low White Blood Cells: The drug can lead to a decrease in white blood cell count, increasing infection risk. Contact your provider if you notice signs of infection.

• Liver and Kidney Issues: Poor liver or kidney function may cause the medication to accumulate, heightening side effects. Frequent monitoring may be required if you have these conditions.

• Myasthenia Gravis: Propafenone might worsen this condition, so consult your provider before beginning treatment.

• Low Sperm Counts: Temporary reduction in sperm count may occur but typically resolves after stopping the medication. Discuss this with your provider if you plan to have children.

Contraindications: Propafenone should not be used in the presence of certain conditions, including heart failure, cardiogenic shock, specific heart rhythm problems without a pacemaker, Brugada syndrome, slow heart rate, dangerously low blood pressure, certain lung conditions, and imbalanced electrolyte levels. Consult your healthcare provider if any of these apply to you before starting treatment.

When taking this medication, you may experience some common side effects, which are usually mild. These include dizziness, headaches, a metallic or salty taste in the mouth, nausea, vomiting, constipation, anxiety, and tiredness. Palpitations, or fast and irregular heartbeats, chest pain, shortness of breath, fatigue, and swelling may also occur. If these effects persist or worsen, it's advisable to consult your healthcare provider.

In some cases, other side effects such as upper respiratory tract infections, influenza, blurred vision, diarrhea, dry mouth, passing gas, weakness, blood in urine, shaking (tremors), sleepiness, and depression have been reported. While these are less common, they should be monitored and discussed with a healthcare provider if experienced.

Serious side effects, although rare, require immediate medical attention. These include abnormal heart rhythm, characterized by chest pain, weakness, dizziness, or fainting; symptoms of heart failure like unexplained weight gain, fluid buildup in legs or feet, and increased shortness of breath; and signs of infection such as fever, sore throat, and chills. Additionally, a severe allergic reaction, which is uncommon, may present with rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, and trouble breathing. If any of these severe reactions occur, seek urgent medical care.

Propafenone, a medication used to manage heart rhythm disorders, can interact with various other drugs, potentially leading to serious effects.

1. Heart Rhythm Medications: Combining propafenone with medications like amiodarone, dofetilide, flecainide, pimozide, procainamide, quinidine, sotalol, and certain antibiotics (e.g., erythromycin, sparfloxacin) can affect the heart's rhythm (QT prolongation). This may result in an increased risk of heart-related side effects.

2. Drugs Affecting Propafenone Removal: Certain medications can influence how propafenone is cleared from the body, which might alter its effectiveness. These include desipramine, ketoconazole, orlistat, phenobarbital, phenytoin, ritonavir, and some HIV protease inhibitors like tipranavir.

3. Impact on Other Medications: Propafenone can slow the elimination of other drugs from your system, affecting their performance. Medications such as digoxin, fezolinetant, imipramine, metoprolol, propranolol, and warfarin are examples.

4. Additional Drug Interactions: There are numerous other medications that, when used with propafenone, require careful management or adjustment by your doctor. These can range from antibiotics and antidepressants to various heart and blood pressure medications.

Due to the complexity and potential severity of these interactions, it is crucial to inform your healthcare provider about all medications and supplements you are taking. Your doctor may need to adjust dosages or find alternative treatments to ensure your safety and the effectiveness of your treatment plan.