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When using this medication, it is crucial to be aware of several important safety considerations to ensure your well-being. Please review the following information carefully and consult your healthcare provider if you have any concerns or questions.

• Heart Health and Discontinuation: Do not stop taking this medication abruptly without consulting your doctor. Sudden cessation can exacerbate certain conditions and lead to serious cardiovascular events such as chest pain, heart attack, or irregular heartbeat. If discontinuation is necessary, your doctor may advise a gradual reduction in dosage over 1 to 2 weeks. During this period, it is advisable to limit physical activity to reduce heart strain. Seek immediate medical attention if you experience any symptoms such as chest pain, discomfort spreading to the jaw, neck, or arm, unusual sweating, breathing difficulties, or a rapid or irregular heartbeat.

• Heart Failure Risks: Since acebutolol slows heart rate, it may worsen certain heart issues, particularly in individuals with heart failure that requires stimulation to maintain blood flow, or in those with heart valve conditions. If you notice symptoms such as shortness of breath, a fast or irregular heartbeat, or swelling in your legs, ankles, or feet, inform your healthcare provider promptly.

• Respiratory Concerns: This medication is typically not recommended for individuals with respiratory conditions like asthma, as it may cause airway constriction and breathing difficulties. Use acebutolol only under the supervision of your healthcare provider if you have lung problems.

• Blood Circulation Issues: Acebutolol can reduce blood flow, potentially worsening conditions related to blood circulation. Notify your provider if you experience symptoms like cramps in the hips or legs, numbness, weakness, or coldness in your lower extremities.

• Diabetes Considerations: For individuals with diabetes, acebutolol can obscure some symptoms of low blood sugar, such as a rapid heartbeat or shakiness, though it might not affect other symptoms like dizziness or sweating. Discuss with your provider how often to monitor your blood sugar levels while on this medication.

• Thyroid Alert: Acebutolol may mask symptoms of an overactive thyroid, such as a rapid heartbeat. Sudden discontinuation could trigger a thyroid storm, a life-threatening condition. Always consult your provider before making any changes to your medication regimen.

• Contraindications: This medication should not be used by individuals with the following conditions due to serious health risks: severe bradycardia, second- and third-degree heart block, overt cardiac failure, or cardiogenic shock. Consult your healthcare provider for guidance if any of these apply to you.

By understanding these risks and precautions, you can use this medication safely and effectively. Always prioritize communication with your healthcare provider for any concerns or symptoms you may experience.

Common side effects:

• Tiredness
• Dizziness
• Headache
• Constipation
• Diarrhea
• Stomach pain or discomfort
• Nausea
• Shortness of breath
• Cold hands and feet

Less common but important to monitor:

• Trouble sleeping
• Passing gas
• Frequent urination

Serious side effects:

• Symptoms indicative of heart failure
• Swelling of the legs, ankles, or feet
• Irregular heartbeat
• Asthma-like symptoms
• Blue fingers or toes
• Fainting
• Very slow heartbeat
• New or worsening symptoms of heart failure
• Mood changes
• Vision changes
• Symptoms of liver disease, like persistent nausea or jaundice
• Severe allergic reaction (rash, severe dizziness, trouble breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• Fingolimod
• Albuterol
• Ceritinib
• Verapamil

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Acarbose
• Aspirin
• Metformin

Interactions with low risk that usually do not require a change in therapy:

• Ibuprofen
• Naproxen