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This medication, Droxia (hydroxyurea), is associated with several important safety concerns that should be noted by patients and healthcare providers alike. Please review the following information carefully and discuss any questions or concerns with your healthcare provider.

• Bone Marrow Suppression: Droxia may reduce bone marrow function, leading to decreased counts of red blood cells, white blood cells, and platelets. This can increase the risk of anemia, infection, and easy bruising or bleeding. Regular blood tests will be conducted to monitor your blood cell levels. Report any signs of infection (like persistent sore throat, cough, fever, or chills), easy bruising or bleeding, pale skin, or unusual fatigue to your doctor immediately.

• Cancer Risk: There is a potential increased risk of developing cancers, such as secondary leukemia and skin cancer, when using Droxia, particularly with long-term use. Protecting your skin from the sun by using sunscreen and wearing protective clothing is recommended. Be vigilant for symptoms of cancer, including swollen glands, unexplained weight loss, night sweats, or unusual skin changes, and inform your doctor if you notice any of these symptoms.

• Pregnancy Concerns: Droxia may harm unborn babies if taken during pregnancy. It is crucial to use effective birth control during treatment and for a specified period after stopping the medication. Females should continue birth control for at least 6 months after stopping Droxia (or Siklos), and males for 1 year after stopping Droxia, or 6 months after stopping Siklos. If pregnancy occurs while taking Droxia, contact your healthcare provider immediately.

• Blood Vessel Damage: Patients with a history of blood cancer or those taking interferon medications may experience blood vessel damage, including leg ulcers. Should any open sores or wounds develop, contact your healthcare provider as your dosage may need adjustment or temporary discontinuation.

• Organ Damage: Pancreatitis, liver damage, and nerve damage have been reported, particularly in patients also taking antiretroviral medications for HIV. Symptoms such as stomach pain, nausea, vomiting, tingling sensations, or jaundice should be reported to your provider promptly for evaluation.

• Lung Issues: Lung damage has been observed in patients taking hydroxyurea for cancer treatment, though not in those using it for sickle cell anemia. Symptoms like fever, chest pain, cough, or difficulty breathing should be immediately reported to your healthcare provider.

Always follow your healthcare provider’s instructions and report any side effects or concerns as soon as they arise.

When taking this medication, some individuals may experience side effects, which can range from mild to serious. Common side effects include nausea, vomiting, loss of appetite, mouth sores, diarrhea, or constipation. These are generally mild but consult your healthcare provider if they persist or worsen. Other frequently reported effects are infections, lower blood cell counts, stomach issues, fever, headache, and low vitamin D levels. These are mostly manageable, but it's important to stay vigilant.

In some cases, users may experience dry skin, joint pain, weakness, dizziness, skin wounds, and cough. While these side effects are not severe, you should inform your healthcare provider if they occur. Occasionally, more serious side effects such as skin problems, mental or mood changes, seizures, shortness of breath, yellowing of the eyes or skin, dark or bloody urine, and signs of kidney problems may arise. If you experience any of these, seek medical attention immediately.

Additionally, very serious allergic reactions, though rare, can occur, presenting as a rash, itching or swelling, severe dizziness, or trouble breathing. Immediate medical help is crucial in such cases. Other serious side effects include chest pain, weight gain, hair loss, swelling, and skin reactions, which demand urgent care. Remember, this is not an exhaustive list of potential side effects. Always communicate with your healthcare provider regarding any concerns or new symptoms you may experience.

When taking Droxia (Hydroxyurea), it's important to be aware of potential interactions with other drugs or supplements. Inform your doctor and pharmacist about all medications and supplements you are using, including prescription, over-the-counter, vitamins, and herbal products.

Some drugs that may interact with Droxia include didanosine and Stavudine. These interactions may lead your doctor to adjust your medication regimen.

Additionally, Droxia can interfere with certain laboratory tests, such as blood sugar tests, potentially leading to inaccurate results. Ensure that all lab personnel and healthcare providers are informed that you are using this medication.

It is generally not recommended to use Droxia with live vaccines such as Measles, Mumps, Rotavirus, Rubella, Varicella, and Zoster vaccines. Similarly, caution is advised with other live vaccines like Adenovirus, Bacillus of Calmette and Guerin, Cholera, Dengue, Influenza, Poliovirus, Smallpox, Typhoid, and Yellow Fever vaccines. If co-administration is necessary, your doctor may adjust the dosing or schedule of these medications to minimize interactions.